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Top 3 Individual Matchups
1 – Donte Whitner vs. Jermichael Finley – After an impressive second NFL season last year, the Packers tight end is poised for a big year in Green Bay’s highly-productive passing attack. Finley is more of a tight receiver than a tight end with great speed for a player his size (6’5” 247). Whitner is likely to serve as the main coverage defender, but the Bills might be wise to mix things up against him knowing how dominant he can be.

2 – Cornell Green vs. Clay Matthews – Matthews was a monster in Week 1 at Philadelphia posting a career high nine tackles, a forced fumble, four QB hits and was eventually credited with three sacks. He’s been dealing with a hamstring injury for much of the preseason and is on the injury report again this week. Buffalo’s veteran right tackle will likely get some assistance from the tight ends and the backs to deal with this handful, who will switch sides as his outside linebacker spot throughout the game.

3 – Lee Evans vs. Charles Woodson – Woodson is dealing with a toe injury so his status is a bit up in the air for Sunday. He’s technically the team’s left cornerback, but figures to be drawing Evans as his primary assignment. Woodson has kicked down into the slot at times, but with Evans being Buffalo’s biggest passing threat, the Packers are expected to put the man who tied Jairus Byrd for a league-leading nine interceptions last season on Buffalo’s top wideout.

Top 2 Bills Advantages
Good Advantage – Pass rush – Green Bay’s pass protection left a lot to be desired last season giving up 50 sacks. They had some issues out of the gate in Week 1 at Philadelphia giving up three sacks as the Eagles had some unique looks defensively. Buffalo’s defenders have said they’ll have some different stuff in this week, and that could pay dividends in getting consistent pressure on Aaron Rodgers.

Best Advantage – Run game – Though Buffalo’s rushing attack did not produce in Week 1 that figures to change in Week 2. The offense intends to re-commit heavily to the ground attack and they’ll be doing it against a Packers defense that surrendered 150 last week.

Bills Number 1 Must
Successful ground game – We saw in Week 1, what can happen to Buffalo’s offense when they can’t run the football. Maintaining at least a capable, if not wildly productive, running game will be essential if the Bills are to be in this one. If they can run, they’ll be able to force the Green Bay defense to respect play fakes and use more play action while controlling the clock and keeping the Packers high-powered offense off the field.

Scouting Eye
Spurt scoring
The Packers vaunted offense was off to an impressive start in Week 1 at Philadelphia. They had an interception and gave up three sacks on their first three possessions, but between the second and third quarters they scored on four straight drives, including 10 points in the final two minutes before the half.  So even when an opponent might have Green Bay down the potential for them to find their rhythm and respond quickly is always present.

Pack lose top tailback
The Packers depth at tailback is being tested early in the season. Starting running back Ryan Grant was lost for the season in Week 1 after he suffered ligament damage in his ankle at Philadelphia. With rookie and UB product James Starks already on Reserve/PUP, Green Bay had just backup Brandon Jackson. They’ve since signed rookie Dimitri Nance off the Atlanta Falcons practice squad.

Jackson and FB John Kuhn are expected to handle the bulk of the rushing duties.

Nicked up defense
Already without starting DE Johnny Jolly, who is serving a league-imposed suspension, the Packers lost DE Justin Harrell for the season with a torn ACL in the opener. Meanwhile their other DE Cullen Jenkins has been limited in practice this week after breaking his hand on the first series of the opener. Rookie backup DE Mike Neal sustained a rib injury in the opener and could not practice on Wednesday and was limited Thursday and that’s just the defensive line.

Primary pass rusher Clay Matthews is working through a hamstring injury that’s been an ongoing thing since the preseason and has been limited in practice this week. Starting CB Charles Woodson is dealing with a toe injury and didn’t practice Wednesday or Thursday and the team is already without their other starting cornerback Al Harris.

Producing on returns
Green Bay’s offense can usually manage if they’re handed poor field position, but that hasn’t been an issue on kickoffs. Kick returner Jordy Nelson averaged a career-best 31.2 yards per return last week, including a long of 51 yards. On his last three returns he provided the Packers with drive starts at their own 36, 40 and 49-yard lines.

Youth in secondary
As much as the Bills will try to establish the ground game on Sunday, they might want to spread the Packers out on a handful of plays. That’s because they’re currently starting a pair of rookies in their nickel defense. Packers third-round pick Morgan Burnett is starting at strong safety next to veteran Nick Collins, while undrafted rookie Sam Shields comes in as the third corner. Testing those rookies in the passing game could prove fruitful.

Deep threat
Greg Jennings is not just the team’s top wideout, he, much like Lee Evans, is the team’s primary deep threat. Proof of that is in his career receiving average of 16.1 yards. Almost half of Jennings’ 29 career touchdown receptions have been 40 yards or more (13), and since 2007 no other NFL receiver has more 40-plus yard receptions than Jennings 21.

Buffalo Chips
Quote of the Week
“We’re a confident bunch. We don’t intend on going out here and letting these guy throw for 400 yards on us and run up and down the football field. We expect to come out and stop them. We expect to get up in their faces and challenge them and make them compete, and that’s what we’re going to do.”
--SS Donte Whitner

Stat of the Week
After Week 1 Trent Edwards’ passer rating is 73.0. After Week 1 Aaron Rodgers’ passer rating is 73.1.

Milestones in Reach
Lee Evans needs one 100-plus yard receiving game to mark the 14^th in his career and tie Frank Lewis for the fourth-most in team history.

Fred Jackson needs 48 rushing yards to reach 2,000 in his career.

Roscoe Parrish needs one punt return for a touchdown for the fourth of his career and sole possession of first place in franchise history.

Final Note
In each of his last three games against AFC opponents, Aaron Rodgers has thrown three or more touchdown passes.