McGee had what head coach Chan Gailey described as "residual soreness" in his knee, which kept him off the practice field on Thursday and Friday.
The soreness stems from knee surgery following the Bills Week 8 game against Houston. McGee suffered the injury in Week 4 at Miami, but played for a month on the injured knee waiting until the bye week to get it taken care of.
He then missed just two games following the procedure and played up until Week 17, when a severe shoulder injury, from a mid-air collision with New England's Randy Moss, forced him to miss the season finale against Indianapolis.
This is the first game that McGee is missing this season.
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