Jackson led the team in rushing and receiving yards in addition to scoring the only touchdown of the day.
Down 10 points early, the Bills were never able to threaten San Diego’s lead in a 22-10 final.
Sunday’s game will be the 34th regular season meeting between Buffalo and Miami, with the Chargers holding a 21-10-2 advantage in the series.
The Bills, after experiencing a painful shortage at the position last year due to injury, fortified the position in the offseason and now find themselves with a surplus on the boundary.
Television, radio, and internet broadcast information for the Bills-Chargers game.
As the San Diego Chargers ready to face the undefeated Buffalo Bills on their home turf at Ralph Wilson Stadium, here are the top 10 reasons why you should be charged up about the matchup.
Since the 2009 season, the West-coast Chargers are 10-8 when playing at 1 p.m. games on the East coast.
Sammy Watkins led all rookie WRs in Week 2 with 117 receiving yards on eight receptions and added his first career touchdown.
The Bills linebacker talks about San Diego's big plays, Philip Rivers, and putting this loss behind them.
The Bills cornerback talks about not making plays against the Chargers offense.
The Bills defensive end talks about Philip Rivers, the Chargers passing game, allowing big plays, and what he learned from the loss.
Chris Brown recaps Sunday's game as penalties by Buffalo and big plays by San Diego keyed a Chargers win in Orchard Park.
Nike brings you inside the locker room as the Bills prepared to take on the Chargers.