We likely won't know until the inactive list comes out on Sunday whether the Bills will have RB Devin Singletary as an option against the Patriots.
The rookie running back practiced on a limited basis for a second consecutive day on Friday, but was limited and is listed as questionable.
"He looked good today," said head coach Sean McDermott following Friday's practice. "We'll see as we get into (Saturday). I'll know more (Saturday) morning."
Out for Sunday's game at TE Tyler Kroft with an ankle injury and LB Corey Thompson, who had ankle surgery earlier this week.
A handful of other players were also listed as questionable. Two new additions Friday were LB Maurice Alexander, who missed Friday's practice with a knee injury, and OL Spencer Long who was limited with an ankle injury.
OL Jon Feliciano (neck), WR Robert Foster (groin), CB Taron Johnson (hamstring), WR Isaiah McKenzie (ankle) were also listed as questionable.
"All those guys are in the same boat," said McDermott. "They all got good work in and we'll get another report on Saturday. Sometimes they work and they get sore, so I don't want to get too far ahead of myself here."
An encouraging sign for both Feliciano and McKenzie is they both practiced fully on Friday. Foster and Johnson were limited.
TE Tyler Kroft - ankle
LB Corey Thompson - ankle
LB Maurice Alexander - knee
OL Jon Feliciano - neck
WR Robert Foster - groin
CB Taron Johnson - hamstring
OL Spencer Long - ankle
WR Isaiah McKenzie - ankle
RB Devin Singletary - hamstring