Location:Ralph Wilson Stadium, Orchard Park, NY
Overall records:Buffalo (3-3), Cincinnati (6-0)
In a Nutshell: **Buffalo's offense got a touchdown on their opening drive for an early lead, but it was almost all Cincinnati after that. Not counting a one-play kneel down at halftime, the Bengals scored on five of their seven possessions to steadily pull away from the Bills in a 34-21 victory and remain undefeated at 6-0.
The Bills offense had both Sammy Watkins and LeSean McCoy back in their starting lineup and though McCoy averaged better than five yards a carry in the game, there weren't enough positive plays in the passing game to keep the chains moving.
EJ Manuel starting in place of the injured Tyrod Taylor was 3-3 passing on the opening scoring drive and scored on a two-yard run. He also threw a 22-yard touchdown pass to Sammy Watkins. All told the offense had five three-and-outs allowing Cincinnati to slowly build a lead Buffalo could not overcome.
Bengals QB Andy Dalton continued his hot play throwing three touchdown passes as Cincinnati eclipsed the 30-point barrier for the third time this season.
Buffalo not only fell to 3-3 on the season, but 1-3 at Ralph Wilson Stadium.
How it went down:--The Bills scored on their opening drive for the first time in three games as EJ Manuel led an 11-play, 80-yard drive that he finished with a two-yard touchdown run. Buffalo went 3-for-3 on third downs on the series.
--Good field position thanks to a taunting penalty gave Cincinnati a drive start near midfield and they capitalized. Andy Dalton hit Jeremy Hill on a swing pass for a 13-yard catch and run for a score to tie the game at seven with three minutes left in the first quarter.
--Cincinnati took their first lead of the game when Gio Bernard shot through a hole on the right side untouched 17 yards to the end zone for a touchdown early in the second quarter (14-7).
--The Bengals tacked on a field goal before the half with Mike Nugent hitting from 47 yards away for a 17-7 lead for Cincinnati midway through the second quarter.
--Buffalo staged a touchdown drive to close the half as EJ Manuel found Sammy Watkins alone in the end zone for a 22-yard scoring strike (17-14). Unfortunately Watkins suffered an ankle injury on the play and did not return.
--Cincinnati scored on their opening drive of the second half marching 90 yards on just eight plays. WR Marvin Jones accounted for 66 of those yards on four receptions including the 10-yard touchdown catch to push the Bengals lead back up to 10 (24-14) early in the third quarter.
--The Bengals then poured it on with Tyler Eifert pulling in his third touchdown in two games with just over a minute left in the third to finish a 12-play drive (31-14).
--Mike Nugent padded Cincinnati's lead with a 39-yard field goal with 10:40 left in the game to put a wrap on another long scoring drive for the Bengals (34-13).
--LeSean McCoy scored his first rushing touchdown of the season on a four-yard run to make it a two-score game with just under seven minutes remaining (34-21), but it would be the final points of the game.
Subplots: **In EJ Manuel's first start in more than a calendar year he went 28-42 passing for 263 yards with a touchdown and an interception and a passer rating of 81.7. He also ran for a touchdown.
Buffalo put together a touchdown drive on their opening possession, making it the first time since their Week 3 game at Miami.
Injuries piled up again for the Bills. Seantrel Henderson (head), Marquise Goodwin (ribs) and Sammy Watkins (ankle) all sustained injuries in the first half of the game and did not return.
LeSean McCoy reached 7,000 career rushing yards in the game. In his return from injury he finished with 90 yards on 17 carries and a touchdown. He averaged 5.3 yards per carry.
Inactives:QB Tyrod Taylor, WR Percy Harvin, RB Karlos Williams, S Josh Bush, WR Marcus Easley, DL Alex Carrington.
Up next:The Bills travel to London to take on the Jacksonville Jaguars in Week 7 for a 9:30 am ET start.
Photos of the action from the Week 6 Bills vs. Bengals game at Ralph Wilson Stadium.