Top Storylines

A sold-out FedEx Field is expected for Sunday's matchup. These important storylines are worth monitoring this week. 

Bouncing back after a Week 1 loss, getting ready for another explosive rushing attack, a new-look Raiders offense + more.

Josh Allen on a MNF stage, Aaron Rodgers vs. Buffalo, Damar Hamlin's return + more.

The race to first place, two of the NFL's hottest teams, Josh Allen vs. a former teammate and more.

The perfect Christmas gift, Josh Allen facing the Bears for the first time, Buffalo's December win streak, Leslie Frazier heading home and more.

A rematch vs. Miami, the state of the AFC East, from one weather extreme to another, defensive line consistency and more.

The AFC playoff picture, a new QB for the Jets, back at home after three weeks on the road and more.

The division gauntlet begins, Buffalo's success over New England, why multiple weapons are needed for Thursday, injury update and more.

How Josh Allen has been great on Thanksgiving, back-to-back games at Ford Field, another test at stopping the run, Detroit's win streak and more.

How the Bills can learn from their mistakes, why the turnover battle is so important, how to stop Nick Chubb a health update and more.

Stefon Diggs set to face former team, James Cook vs. Dalvin Cook, stopping the run and more to know for Sunday's game.

Josh Allen's career stats vs. Jets, two top 10 defenses, WRs going up against Sauce Gardner and more.

The Bills are back on primetime this week. These six factors will have a lot to do with how this matchup plays out.

Moving on from :13 seconds, two of the best QBs facing off & a new look Chiefs WR corps 

Kenny Pickett's first NFL start and who on the Bills has familiarity with him, how the injury bug has hit both teams and more.

Josh Allen and Lamar Jackson lead dynamic offenses, injury updates, a great third down offense and more.

A divisional matchup featuring two undefeated teams, the NFL's best wide receivers on display, a homecoming for several Bills, injury watch and much more.

A home opener on a primetime stage, facing another good pass rush, stopping Derrick Henry and more.

Taking on the defending Super Bowl champs, Von Miller going up against his former team, Josh Allen's first game in California + more.

Plenty of history between the Bills and Chiefs, Allen-Mahomes the NFL's top QB rivalry? Will Sunday will be the toughest game yet for Buffalo's secondary + more.

Playoff history vs. the Patriots, why the Bills and Patriots were opposites to end the regular season, the defense's monstrous end to the season, weather report + more.

Division title on the line, a chance to sweep the Jets again, Devin Singletary's hot stretch, milestones to watch for and more.

Playoff chances, Josh Allen's streak, Bills WR options, two playmakers the Bills need to stop and more.

The rematch, why red zone execution is so important, how Covid-19 could affect who's available and more.

Two teams desperate for wins, why Carolina's defense is one of the best, the potential to face two quarterbacks and more.

Strength vs strength, attacking through the air, and facing Tom Brady

A battle for first place in the AFC East, two of the best defenses, two different offenses, a big stage on MNF and more.

A fight to stay alive in the playoff race, another opportunity to stop the run, the Thanksgiving stage, plus more storylines to follow.

A playoff rematch, Bills offense back on track, stopping Jonathan Taylor and more.

Turning a loss into a learning opportunity, preparing for multiple Jets quarterbacks, offensive line health and a look at the AFC East standings.

How Sean McDermott fares against rookie quarterbacks, how the Bills have been dominant in this category, an offensive line that could continue its shuffling and more.

Buffalo's dominance over Miami, Josh Allen's 50th career start, Miami's tough streak, Sean McDermott undefeated following a bye and more.

How Buffalo has fared against Tennessee in recent history, taking down Derrick Henry, primetime Josh Allen and more.

How an AFC Championship loss led the Bills to change, how to limit Patrick Mahomes and his weapons, why it's important to respect Kansas City's defense and more.

Can the Bills handle business as a heavy favorite, another young quarterback comes to town, will the offense continue its hot streak - here's what to watch for this week.

A head coaching reunion, a team record on the horizon for Josh Allen, former Bills return to Orchard Park plus more to follow in this week's Bills vs. Washington matchup.

Buffalo's recent success against Miami, the Bills offense is ready to bounce back, Tua in year 2 and more.

The last two matchups against Pittsburgh, Josh Allen vs. Ben Roethlisberger, a new OC in Pittsburgh and more.

To play or rest, Miami's playoff hopes, a shot at FitzMagic and more in this week's top storylines.

Sights set on a No. 2 seed, more records to break, a chance to sweep the Patriots and more in this week's top storylines.

One win away from claiming the AFC East, can the defense continue their takeaway streak, Stefon Diggs close to breaking more records and more in this week's top storylines.

A game that matters for both teams, a Steelers team that's on their third game in 11 days, the Bills explosive offense could be the perfect match for a talented Steelers defense and more in this week's top storylines.

Another chance at State Farm Stadium, an opportunity for the first Bills MNF win this century, a look at two talented coordinators and more in this week's top storylines to know.

Sean McDermott is undefeated following a bye, another tough test for the secondary, a chance to turn the run game around and more in this week's top storylines.

Two mobile quarterbacks, DeAndre Hopkins vs. Tre'Davious White, best offseason acquisitions and more in this week's top storylines.

The MVP frontrunner comes to town, warm weather is expected, and the Bills are gunning for a 7-2 mark for the first time in 27 years. Check out the top storylines for this week's clash against Seattle.

The Bills are looking for their first win over the Patriots since 2016. This will be a big game at Bills Stadium on Sunday.

How the offense and defense can get back on track, a chance to sweep the Jets, a look at the AFC East through six games and more in this week's top storylines.

A matchup against the Super Bowl Champs, Josh Allen vs. Patrick Mahomes, Sean McDermott faces the coach who taught him the most and more in this week's top storylines to know.

Bills look for first 5-0 start since 1991, how are the Titans dealing with COVID-19, fans are set to be on-hand in Nashville - these are just a few of the top headlines heading into Sunday's game in Nashville.

Buffalo's first game in Allegiant Stadium, the potential of another high scoring game, Alabama ties and more.

First game out of conference, key matchups, the battle of the Seans and more in this week's top storylines.

Reporter Maddy Glab shares the storylines she's following as the Bills prepare for their first road game of the 2020 season.

Josh Allen vs. Sam Darnold, how the Jets are dealing with low expectations, social justice initiatives and more in this week's top storylines.

How will Josh Allen perform in his playoff debut? Can the Bills win their first playoff game since 1995? Will the vaunted Bills defense slow down Houston's potent offense? John Murphy breaks down the top storylines heading into Saturday's playoff game.

John Murphy breaks down the top storylines heading into the season finale against the New York Jets.  Sean McDermott announced the starters will play on Sunday but he did not commit to how long they will be in.

Can the Bills earn their seventh road win for first time in franchise history? Can they move into a tie for first place in the AFC East? Will Josh Allen earn his first win against Buffalo's nemesis? John Murphy breaks down the top storylines for Saturday's clash in New England.

There's a lot on the line for the Bills in Sunday's game in Pittsburgh. The Bills can clinch a playoff spot with a win, the team will play its first Sunday Night Football game in 12 years and Tremaine Edmunds will look to get a win against his brothers - Trey and Terrell. John Murphy breaks it all down.

Buffalo Bills return home with a three-game win streak and a chance to clinch a playoff berth. However, they face the Baltimore Ravens - currently the AFC's top team and riding an eight-game win streak. John Murphy breaks down one the biggest games to come Buffalo in 28 years.

The Bills are 8-3 and in the thick of the AFC playoff race. They'll have a short week to prepare to face Dallas and its league-leading offense on Thursday - Thanksgiving Day. John Murphy breaks down the top storylines heading into gameday.