They both left with ankle sprains in Sunday's game and did not return. According to head coach Chan Gailey right guard Kraig Urbik and left tackle Cordy Glenn will both be on the shelf for the next couple of games.
"It may be two (weeks) minimum on both of them, but we're not going to rule out the second game today," said Gailey Monday. "I've not been very good about doing that lately, so we're going to say it's probably two but I don't know about that."
Urbik left Sunday's game in the first quarter with what he confirmed was a high-ankle sprain. He was hobbling around the locker room Monday in an immobilizer boot.
"It's always a disappointment to lose a game like that and to go out in the first quarter like that is always heartbreaking to not finish the game," said Urbik. "I'm going to take it day by day and see how it goes from here on out."
For Urbik the injury is particularly frustrating because it's the third straight season he's missed time due to injury. He missed three games last season and was placed on injured reserve toward the end of the 2010 season.
"You can't really avoid it if a guy falls on your legs," he said. "It's a part of football and it happens sometimes and unfortunately it's happened to me each of the past three years."
Urbik will be replaced in the lineup by veteran Chad Rinehart, who has appeared in 20 games for the Bills over the past two seasons.
Glenn's injury was also an ankle, as he too had his leg rolled up on from behind at the end of a pass play late in the third quarter.
The left tackle walked off the field under his own power, but his ankle was bent awkwardly inward as it was caught under the pile on a Ryan Fitzpatrick sack.
Glenn will be replaced by Chris Hairston, who started seven games at left tackle last season.
Byrd, Chandler, Jones all recoveringS Jairus Byrd, TE Scott Chandler and WR Donald Jones all left Sunday's game with injuries. Byrd's hip contusion is not considered serious.
"It'll take a few days to get it moving again, but I think he'll be fine," said Gailey.
Gailey said all indications are Chandler and Jones will be fine looking ahead to the team's Week 5 game at San Francisco.