They're already without their top two quarterbacks and best cover corner. EJ Manuel is still recovering from knee surgery while Kevin Kolb is out indefinitely with a concussion. And Stephon Gilmore could miss the first half of the season with a fractured wrist. On Thursday night in their preseason finale they may have lost two more for a period of time.
Bills second team left guard Doug Legursky was carted off the field after his left knee was caved in on the back side of a run play near the end of the third quarter.
"Doug doesn't look good," said head coach Doug Marrone. "It's a knee. I don't know. I'm thinking without it being evaluated that it's probably major without having it officially deemed that."
Losing Legursky leaves the Bills with just one experienced reserve guard behind projected starters Kraig Urbik and Colin Brown in Antoine Caldwell.
Meanwhile at receiver Brad Smith went to the locker room after taking a shot to his ribs on his last kick return of the first half. He came to the sidelines under his own power, but was wincing.
"Brad Smith is ribs so I think they'll take some x-rays and they'll see that and if it's a contusion and it's just a hit and it's bruised then obviously that's less, but if it's broken usually it's a couple of weeks," said Marrone.
Bills receiver Marquise Goodwin also left the game in the first half with an eye injury and did not return, but is going to be okay.
"Goodwin is fine," said Marrone. "He just got a little scratch on his eye, but it wasn't anything where he had broken blood vessels or anything."
When asked if he was concerned about his team's depth Marrone had a short reply.
"I am," he said.