Bills head coach Sean McDermott provided an injury update on Matt Milano (knee/lower leg) and DaQuan Jones (pec) on Monday afternoon.
"Both are going to be out," McDermott said. "Matt has a leg injury that requires surgery and DaQuan has a pec (injury) that requires surgery."
McDermott said he is not sure if either injury will be season ending for Milano and Jones.
Milano and Jones left Sunday's game against the Jaguars and did not return due to injury.
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In five games this season, Milano racked up two interceptions (tied for team lead), two passes defensed, one forced fumble, one tackle for loss and 30 total tackles.
Jones registered two and a half sacks, five quarterback hits, three tackles for loss and 10 total tackles in five games to start the season.