1) Thurman Thomas (1988-99)
11,983 career yards, 65 rushing touchdowns
![thomas-all-time-story.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/bills/v16lanuyp7u58rizm8ev.jpg)
2) O.J. Simpson (1969-1977)
10,183 career yards, 57 rushing touchdowns
![simpson-all-time-story.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/bills/qcb55h1pvu9pxnrhtlsu.jpg)
3) Fred Jackson (2007-present)
5,127 career yards, 28 rushing touchdowns
![jackson-all-time-story.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/bills/rig7e8b8zshlsaypo3c2.jpg)
4) Joe Cribbs (1980-83, 85)
4,445 career yards, 21 rushing touchdowns
![cribbs-all-time-story.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/bills/id5a43jyrcestdqq6qus.jpg)
5) Travis Henry (2001-04)
3,849 career yards, 27 rushing touchdowns
![henry-all-time-story.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/bills/gk5a8d7vnu8yqwrk4kfe.jpg)
6) Wray Carlton (1960-67)
3,368 career yards, 29 rushing touchdowns
![carlton-all-time-story.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/bills/tsewocgd3o6fslt6wmhb.jpg)
7) Willis McGahee (2004-06)
3,365 career yards, 24 rushing touchdowns
![mcgahee-all-time-story.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/bills/l76onbbd4c6ifdx17iil.jpg)
8) Cookie Gilchrist (1962-64)
3,056 career yards, 31 rushing touchdowns
![gilchrist-all-time-story.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/bills/auncrpld8tfqcyz5pwht.jpg)
9) C.J. Spiller (2010-present)
3,015 career yards, 12 rushing touchdowns
![spiller-all-time-story.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/bills/la3lkjel7kvolm3uj43z.jpg)
10) Antowain Smith (1997-2000)
2,932 career yards, 26 rushing touchdowns
![smith-all-time-story.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/bills/ogshcnqrif1db91ubj8i.jpg)