Bills vs. Lions Highlights | Josh Allen scores 5 TDs in HISTORIC home opener

NFL Highlights from the Buffalo Bills 41-31 victory over the Detroit Lions. QB Josh Allen threw for 3 touchdowns and ran for two more as Buffalo wins its first regular season Highmark Stadium.

Buffalo Bills running back James Cook's best plays from his 139-yard game vs. the Detroit Lions during Week 2 of the 2026 NFL season.

Buffalo Bills quarterback Josh Allen's best plays from his five touchdown game vs. the Detroit Lions in Week 2 of the 2026 NFL season.

Buffalo Bills running back James Cook scores his first touchdown of the 2026 NFL season.

Bills RB James Cook's wicked juke move sparks 22-yard run that nearly yields pylon access. Bills-Lions Highlights.

Buffalo Bills quarterback Josh Allen scores his second rushing touchdown of the night.

Buffalo Bills outside linebacker Bradley Chubb sack's Detroit Lions quarterback Jared Goff.

Buffalo Bills quarterback Josh Allen's throws his third touchdown pass of first half to tight end Dalton Kincaid.

Bills RB James Cook rushes for a 35-yard Gain vs. Detroit Lions, 09/17/2026

Buffalo Bills quarterback Josh Allen throws this fourth touchdown pass of the 2026 NFL season to tigt end Dawson Knox.

Buffalo Bills quarterback Josh Allen throws a 22-yard pass to Coleman.

Buffalo Bills linebacker Greg Rousseau sack's Detroit Lions quarterback Jared Goff for the second time in the first quarter.

Buffalo Bills quarterback Josh Allen throws a 25-yard pass to tight end Dalton Kincaid.

Can't-Miss Play: 43-yard TD! Josh Allen uncorks deep scoring strike to wide-open Josh Palmer on 'TNF'

Buffalo Bills Greg Rousseau's sack's Detroit Lions quarterback Jared Goff forcing a punt on first drive.

Buffalo Bills QB Josh Allen rushes for a 1-yard Touchdown vs. Detroit Lions marking the first TD at Highmark Stadium.

Watch the best plays by the Buffalo Bills in their 36-31 victory against the Houston Texans in Week 1 of the 2026 NFL season.

Buffalo Bills play the Houston Texans at Reliant Stadium on 09/13/2026

Watch the best plays from Buffalo Bills quarterback Josh Allen against the Houston Texans in Week 1 of the 2026 NFL season.

Watch every catch by Buffalo Bills wide receiver DJ Moore in a 100-yard game against the Houston Texans in Week 1 of the 2026 NFL season.

Buffalo Bills defensive tackle Deone Walker sacks Texans quarterback C.J. Stroud.

Buffalo Bills linebacker Greg Rousseau strip-sacks Texans quarterback C.J. Stroud and linebacker Terrel Bernard recovers.

Buffalo Bills quarterback Josh Allen completes a 34-yard touchdown pass to wide receiver Josh Palmer.

Buffalo Bills quarterback Josh Allen completes a 35-yard pass to tight end Dalton Kincaid.

Buffalo Bills quarterback Josh Allen completes a 40-yard pass to tight end Dalton Kincaid.