Can't-Miss Play: Former rugby star Christian Wade runs for 65-yard TD

Best Buffalo Bills defensive end Greg Rousseau plays vs. Chiefs during Week 5 of the 2021 season.

Josh Allen earned his first win over Kansas City with a big time performance.

The Bills defeated Kansas City 38-20 in a rematch of the 2020 AFC Championship game.

Can't-Miss Play: Jumpman Josh! Buffalo Bills quarterback Josh Allen's INSANE third-down hurdle keeps the chains moving.

Emmanuel Sanders recorded his second touchdown of the night on this bullet from Josh Allen.

Rookie Greg Rousseau produces his first career interception.

Micah Hyde produced his first career pick-six on this play.

Dawson Knox eclipsed the 100-yard receiving mark with this catch.

The Buffalo Bills defense holds strong in coverage for eight seconds on fourth down against Kansas City Chiefs quarterback Patrick Mahomes.

Dawson Knox catches a touchdown pass in his fourth consecutive game.

Josh Allen finds Stefon Diggs for a 61-yard gain.

Josh Allen finds Emmanuel Sanders for a 35-yard touchdown pass.

Kansas City Chiefs outside linebacker Anthony Hitchens loses track of Buffalo Bills running back Zack Moss on a 24-yard catch and run.

Buffalo Bills cornerback Siran Neal is a heat-seeking missile on his forced fumble versus Kansas City Chiefs wide receiver Byron Pringle.

Buffalo Bills quarterback Josh Allen puts some heat behind a 23-yard dart to Bills tight end Dawson Knox.

Josh Allen scored the game's first touchdown on this designed run.

Buffalo Bills quarterback Josh Allen locates a crease and sprints through it for 22 yards.

Watch all of the Buffalo Bills' best defensive plays from a shutout win in Week 4 of the 2021 season.

Watch every catch by Buffalo Bills wide receiver Stefon Diggs from his 114-yard game in Week 4 of the 2021 season.

Buffalo Bills quarterback Mitchell Trubisky fools the Houston Texans' defense on a sneaky touchdown bootleg run.

Bills shut out Houston 40-0 in a Week 4 win from Highmark Blue Cross Blue Shield Stadium in Orchard Park, N.Y.

Moss scored in his third straight game.

Bills' play design frees up Dawson Knox for his second touchdown of the game.

Buffalo Bills quarterback Josh Allen dials launch codes to Stefon Diggs for 37 yards

For the second consecutive week, Micah Hyde produced an interception.