Can't-Miss Play: Former rugby star Christian Wade runs for 65-yard TD

As we count down to the NFL 100th and Bills 60th seasons, we’re looking back at some of the players and moments that made Bills history.

See every target to Buffalo Bills wide receiver Cole Beasley in the Preseason Week 2 matchup against the Carolina Panthers.

Watch the highlights from the Preseason Week 2 matchup between the Buffalo Bills and the Carolina Panthers.

Buffalo Bills running back Christian Wade runs 48 yards on a pass from quarterback Tyree Jackson.

Buffalo Bills quarterback Tyree Jackson runs for 20 yards against the Carolina Panthers.

Buffalo Bills wide receiver Duke Williams catches a 9-yard touchdown pass from quarterback Matt Barkley,

Buffalo Bills wide receiver Isaiah McKenzie runs 37 yards off a pass from quarterback Matt Barkley.

Buffalo Bills cornerback Kevin Johnson returns an interception by Carolina Panthers quarterback Will Grier for a touchdown.

Buffalo Bills defensive end Trent Murphy sacks Carolina Panthers quarterback Kyle Allen on fourth down.

Buffalo Bills wide receiver Andre Roberts runs a punt return back for 37 yards.

Buffalo Bills running back LeSean McCoy rushes one-yard for a touchdown.

Buffalo Bills defensive tackle Ed Oliver knocks down a pass from Carolina Panthers quarterback Kyle Allen.

Buffalo Bills quarterback Josh Allen passes 25 yards to tight end Tommy Sweeney.

Buffalo Bills quarterback Josh Allen passes 22 yards to tight end Tommy Sweeney.

See the best plays from the Preseason Week 1 matchup between the Indianapolis Colts vs. Buffalo Bills.

Watch every Buffalo Bills rookie running back Devin Singletary touch in Preseason Week 1 vs. Indianapolis Colts.

Buffalo Bills running back and former rugby star Christian Wade runs for 65-yard touchdown.

Buffalo Bills running back Senorise Perry dives over Indianapolis Colts' defense for 1-yard touchdown.

Buffalo Bills safety Dean Marlowe returns interception to red zone/

Buffalo Bills quarterback Matt Barkley completes 38-yard pass while being tackled.

Buffalo Bills rookie running back Devin Singletary barrels through Colts' defense to convert third down.

Buffalo Bills quarterback Matt Barkley finds wide receiver Cam Phillips in back of end zone for touchdown.

Buffalo Bills quarterback Josh Allen lofts finds wide receiver Zay Jones for 23 yards.

Buffalo Bills wide receiver Cole Beasley records first catch in Bills preseason debut.

In this edition of "Coming This Fall" presented by New Era, we feature the best moments from Bills' Defensive End, Jerry Hughes.