John Murphy breaks down the Bills' matchup vs the Indianapolis Colts at Lucas Oil Stadium.
Take a look at some of the top defensive plays made by the Bills through the first 10 weeks of the season.
Watch complete highlights from the Week 10 matchup between the Buffalo Bills and the New York Jets.
Watch Matt Barkley's Week 10 performance where he throws for 232 yards and 2 touchdowns in a 41-10 win over the Jets.
Watch Buffalo Bills running back LeSean McCoy highlights in Week 10 vs. New York Jets.
All Interceptions from Buffalo Bills vs. New York Jets, 11/11/2018
All Sacks from Buffalo Bills vs. New York Jets, 11/11/2018
Buffalo Bills safety Micah Hyde intercepts Jets quarterback Josh McCown's pass.
Buffalo Bills quarterback Matt Barkley finds Zay Jones in the end zone for a 8-yard touchdown.
Buffalo Bills quarterback Matt Barkley lobs the ball to wide receiver Robert Foster for a 43-yard completion.
Buffalo Bills running back LeSean McCoy receives the handoff and pushes his way into the end zone for a 1-yard touchdown.
Buffalo Bills running back LeSean McCoy shows off his footwork with a nice spin move for a 23-yard gain.
Buffalo Bills linebacker Matt Milano intercepts Jets quarterback Josh McCown and returns if for a 29-yard gain.
Buffalo Bills quarterback Matt Barkley finds offensive tackle Dion Dawkins who gets a 7-yard touchdown.
Buffalo Bills kicker Stephen Hauschka makes 54 yard field goal and is now tied at 50 on the NFL's all-time field goal list.
Buffalo Bills quarterback throws a 33-yard strike to wide receiver Zay Jones
Buffalo Bills line up for a punt, but tight end Logan Thomas throws the ball for a first down.
Buffalo Bills wide receiver Zay Jones fumbles the ball in the end zone and tight end Jason Croom recovers the ball in the end zone for another Bills touchdown.
Buffalo Bills quarterback Matt Barkley hands the ball off to running back LeSean McCoy who runs it into the end zone for a 28-yard touchdown.
Buffalo Bills quarterback Matt Barkley launches the ball 47 yards to wide receiver Robert Foster on the first play of the game.
John Murphy breaks down the Bills week 10 matchup vs the NY Jets at Metlife Stadium.
In this week's episode of Inside the Film Room, HC Sean McDermott and Steve Tasker break down the plays made by some of younger Bills' players against the Chicago Bears in Week 9.
Watch the highlights from the Week 9 matchup between the Chicago Bears and the Buffalo Bills.
Buffalo Bills quarterback Nathan Peterman pushes his way into the end zone for a score.
Buffalo Bills cornerback TreDavious White intercepts the Chicago Bears quarterback Mitchell Trubisky and returns it for 37 yards.
Buffalo Bills linebacker Julian Stanford sacks Chicago Bears quarterback Mitchell Trubisky for a loss of 7 yards.