1. Can the Bills offense sustain its success?
Coming off of last Sunday's offensive outburst in which Buffalo's attack racked up a season-high 37 points and 424 total net yards, the challenge now is to keep that rate of production going.
The task figures to be much harder against a Denver defense that ranks fourth overall, fifth against the pass and seventh in points allowed.
As head coach Sean McDermott sees it, it's about focusing in on the part of their game where they can make an impact.
"I think it's all what we can control. That's really where our focus is and making sure we continue to build on that with the right mindset, fundamentals and technique," he said. "That leads to great execution. Just continuing to grow as a football team, in this case on the offense.
"It's a good defense that we're going to play this week, so we have a lot of respect for them and the preparation that's going to need to go into that (to be productive)."
2. Injury updates on Ty Nsekhe and Siran Neal
Bills offensive tackle Ty Nsekhe won't be practicing on Wednesday due to the ankle injury he suffered last week at Miami that forced him to be carted from the field. Nsekhe's prognosis was provided by coach McDermott.
"Ty Nsekhe won't practice," said McDermott. "He's week to week with the ankle. We'll see how he does."
With Nsekhe not available, the platoon that's taken place between the veteran lineman and rookie Cody Ford will be presumably be put on hold, with Ford likely to see the full complement of reps. The Bills second-round pick will have a formidable test this week in perennial Pro Bowl pass rusher Von Miller set to line up opposite him on Sunday.
Jerry Hughes and Siran Neal are also non-participants for Wednesday's practice due to a groin injury and a concussion. McDermott confirmed that Neal is in the concussion protocol.
John Brown and Lorenzo Alexander are both getting veteran rest days and won't practice either.
3. Corey Liuget blending in well
It's only been two weeks, but the Bills haven't been shy in making veteran defensive tackle Corey Liuget a part of their defensive line rotation.
Signed on the Tuesday before the Cleveland game a couple of weeks ago, Liuget has been thrown right into the lineup and by coach McDermott's account has played admirably.
"He did a good job this past week in particular," said McDermott of Liuget. "I believe the more he's around our system and the more comfortable he gets, the faster he'll play. There was evidence of that last week. He really does some good things that the other guys in the room could stand to learn from as well. That veteran experience, from a fundamental and technique standpoint is good for us."
Against the Browns, Liuget received 24 percent of the snaps in Week 10. This past Sunday, his time on the field increased to 28 percent, and could expand even further this coming weekend against Denver.