Rich Cimini's pick:This is a bad matchup for the Jets. Sam Darnold is coming off a one-month layoff, which means he'll be rusty in the first cold-weather game of his life. Buffalo's zone-based defense will cause problems for the Jets, who have only three offensive touchdowns in the past five games. Bills 23, Jets 12
Mike Rodak's pick:The Bills are favored by Vegas for the first time this season, and for good reason: They walloped the Jets 41-10 with fill-in quarterback Matt Barkley last month at MetLife Stadium. I would expect some regression by Josh Allen, whose 83.6 Total QBR in his two games since returning from an elbow injury has exceeded his 53.0 mark for the season. But the opportunity still exists for Allen to have another big game against a Jets defense that has given up an NFL-worst 450.7 yards per game since (and including) its loss to Buffalo. Bills 26, Jets 20
