Game Recap

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Colts 41, Bills 15 | Game recap, highlights & photos

Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert


Highmark Stadium, Orchard Park, NY

Final score:

Colts 41, Bills 15


Bills (6-4), Colts (6-5)

Next opponent:

Bills at New Orleans Saints (5-5) on Thanksgiving night, Thursday, November 25 on NBC

Click here to see the full box score from today's game.

Here's a list of notable notes from today's game …

  • Bills fall to 6-4 and now sit a half game behind the New England Patriots (7-4) in the AFC East
  • Bills suffered their first home loss in the month of November since Nov. 4, 2018 (41-9 vs. Chicago)
  • Bills produced 307 total yards and extended their streak of 20 games with at least 300 yards - the longest active streak in the NFL
  • Bills snapped their streak of 18 games leading or tied at halftime – was the longest streak in the NFL coming into the game
  • Tyler Bass snapped his streak of 16 consecutive made field goals – also the longest streak in the NFL coming into the game
  • Stefon Diggs and Josh Allen connected on their 12th & 13th touchdown passes
  • Diggs now has 44 career touchdown receptions, 14 with the Bills and six in 2021
  • Allen now has 21 passing touchdowns in 2021 and 88 career touchdown passes
  • Sean McDermott coached in his 74th career game with the Bills – the third highest total in team history passing Chuck Knox

Scroll to see the best photos from the Bills' Week 11 game against the Indianapolis Colts at Highmark Stadium.