Location:
Highmark Stadium, Orchard Park, NY
Final score:
Colts 41, Bills 15
Records:
Bills (6-4), Colts (6-5)
Next opponent:
Bills at New Orleans Saints (5-5) on Thanksgiving night, Thursday, November 25 on NBC
Click here to see the full box score from today's game.
Here's a list of notable notes from today's game …
- Bills fall to 6-4 and now sit a half game behind the New England Patriots (7-4) in the AFC East
- Bills suffered their first home loss in the month of November since Nov. 4, 2018 (41-9 vs. Chicago)
- Bills produced 307 total yards and extended their streak of 20 games with at least 300 yards - the longest active streak in the NFL
- Bills snapped their streak of 18 games leading or tied at halftime – was the longest streak in the NFL coming into the game
- Tyler Bass snapped his streak of 16 consecutive made field goals – also the longest streak in the NFL coming into the game
- Stefon Diggs and Josh Allen connected on their 12th & 13th touchdown passes
- Diggs now has 44 career touchdown receptions, 14 with the Bills and six in 2021
- Allen now has 21 passing touchdowns in 2021 and 88 career touchdown passes
- Sean McDermott coached in his 74th career game with the Bills – the third highest total in team history passing Chuck Knox
Scroll to see the best photos from the Bills' Week 11 game against the Indianapolis Colts at Highmark Stadium.
![game-photos-beasley-cover](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_png/bills/vx2cz1ncrnovnhu1xndp.png)
![Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Billy Buffalo](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/lddxfj0rcvkehfwec4bq.jpg)
Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Billy Buffalo
![Harrison Phillips (99) and Taron Johnson (24) Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021.
Photo by Craig Melvin](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/jgxif5mizqwtvhykwpyr.jpg)
Harrison Phillips (99) and Taron Johnson (24) Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021. Photo by Craig Melvin
![Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021.
Photo by Craig Melvin](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/bzdxow2isnbsfo8hazah.jpg)
Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021. Photo by Craig Melvin
![Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021.
Photo by Craig Melvin](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/igbgrvmayghcoqldkwrr.jpg)
Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021. Photo by Craig Melvin
![Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021.
Photo by Craig Melvin](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/fdexiatt1xyw6tkd4xly.jpg)
Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021. Photo by Craig Melvin
![Matt Milano (58) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/cdjayqmtyk511o1gjbuy.jpg)
Matt Milano (58) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/t8kdhldautk9nuuedbg3.jpg)
Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/pn6mof9hrpiprm45nlni.jpg)
Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Devin Singletary (26) Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021.
Photo by Craig Melvin](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/aslbqqeryrdn2gxjbuvn.jpg)
Devin Singletary (26) Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021. Photo by Craig Melvin
![Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/cygfygyrlbgqcqoz6hdn.jpg)
Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Greg Rousseau (50) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/mbzo8tlp01cho5s5ggcv.jpg)
Greg Rousseau (50) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Taron Johnson (24) Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021.
Photo by Craig Melvin](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/t9yezfewshzuriwp3ncf.jpg)
Taron Johnson (24) Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021. Photo by Craig Melvin
![Cole Beasley (11) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/wcfkvnbibswhjcmscr8g.jpg)
Cole Beasley (11) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Matt Breida (22) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/gduswfie89xvqi0lnwp7.jpg)
Matt Breida (22) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Cole Beasley (11) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/jl7xvmjihxlb2uhjmd0u.jpg)
Cole Beasley (11) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/dodndm7m5tzcmyrp3vi9.jpg)
Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/jrqyjxej4xx1csogpscc.jpg)
Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Stefon Diggs (14) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/nkqgybluyk1qtxspzxlr.jpg)
Stefon Diggs (14) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Vernon Butler (94) and A.J. Epenesa (57) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/cfldgq332c7cjc2bksxm.jpg)
Vernon Butler (94) and A.J. Epenesa (57) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green
![Cody Ford (74) and Tyler Bass (2) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/uj6sn0eiwhitoflepkgj.jpg)
Cody Ford (74) and Tyler Bass (2) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green
![Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/tkmfenagisgkwwrwax1p.jpg)
Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/y1nqvqfncopoh3co2o87.jpg)
Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Taiwan Jones (25) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/xtzole9o1689nkhpekwb.jpg)
Taiwan Jones (25) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/cmszgaki6j2r3lt3cnd7.jpg)
Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Boogie Basham (96) Vernon Butler (94) and Greg Rousseau (50) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/o3vdu0ri9ygu20wplgrh.jpg)
Boogie Basham (96) Vernon Butler (94) and Greg Rousseau (50) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green
![Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/sspjc2xgfxftddbc4we2.jpg)
Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green
![Matt Breida (22) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/kxmyoec5soht7xuglmne.jpg)
Matt Breida (22) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green
![Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/lcmgg9uk6cmvzkoevea4.jpg)
Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green
![Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/kimergd2yiaek1fsusse.jpg)
Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green
![Tre'Davious White (27) and A.J. Klein (54) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/jwmsaob1fzsgkx8fcalj.jpg)
Tre'Davious White (27) and A.J. Klein (54) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green
![Greg Rousseau (50) Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021.
Photo by Craig Melvin](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/ad8fmcozg2pnkskkbnwv.jpg)
Greg Rousseau (50) Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021. Photo by Craig Melvin
![Dawson Knox (88) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/ddwenimxwlnjgjtr3apz.jpg)
Dawson Knox (88) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/zmoufbgb3tndjwwyeg6b.jpg)
Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Josh Allen (17) 2-point conversion run. Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/b3xoden6p4bvqupqxjzm.jpg)
Josh Allen (17) 2-point conversion run. Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green
![Tyler Bass (2) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/pdnhjdc2o6cmpetjgkp5.jpg)
Tyler Bass (2) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Matt Milano (58) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/dgexqbpaa0quha1q7eby.jpg)
Matt Milano (58) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Ben Green
![Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021.
Photo by Craig Melvin](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/zjsrgw1bdk30wt5y57sy.jpg)
Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021. Photo by Craig Melvin
![Tre'Davious White (27) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/f9n2wzom71roshr02gfx.jpg)
Tre'Davious White (27) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/usd2u6dki9vyaicjrzen.jpg)
Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Ed Oliver (91) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/wokxzv1zcagoujna5zn3.jpg)
Ed Oliver (91) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021.
Photo by Craig Melvin](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/mwh46cctm4j18xvikcaq.jpg)
Stefon Diggs (14) touchdown Buffalo Bills vs Indianapolis Colts at Highmark Stadium on November 21, 2021. Photo by Craig Melvin
![Ed Oliver (91) sack of Carson Went (2) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/ywk3kkuql5a9dmvc1a3o.jpg)
Ed Oliver (91) sack of Carson Went (2) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/mzrc0404h7t8e2xhtax2.jpg)
Josh Allen (17) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Ed Oliver (91) sack of Carson Wentz (2) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/wal4ykenhccyms4qmd8d.jpg)
Ed Oliver (91) sack of Carson Wentz (2) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Matt Breida (22) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/jflcb9xmikagdigfvocs.jpg)
Matt Breida (22) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert
![Stefon Diggs (14) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/bills/rv8p3qnchcmowhvveltn.jpg)
Stefon Diggs (14) Buffalo Bills vs Indianapolis Colts at Highmark Stadium, November 21, 2021. Photo by Bill Wippert