The Buffalo Bills hit the practice field on Wednesday for the first time since defeating the Detroit Lions 41-31 in Week 2. Looking ahead to a home matchup with the Los Angeles Chargers, Buffalo has begun preparing for another chance to remain unbeaten.
Here's what we learned after the five-day break.
Scouting the Chargers
Coming into Week 3, the Bills are tasked with an opponent flying in from the West Coast. The Chargers lost two consecutive home games by double digits to start the year against teams who finished the 2025 season with a sub-.200 win percentage.
Despite Los Angeles's struggles to start the year, Buffalo wants to treat Sunday like any other game.
"The record, the opponent, none of that should have any bearing on our preparation and the way that we go into the football game with the same mindset," head coach Joe Brady said. "If we're playing a team in Week 10 that's 10-0, and we approach that any differently than if it's a team that's 0-10, then shame on us. I'm not doing a good job as a coach."
Chargers QB Justin Herbert presents a unique skill set for the Bills defense to gameplan against. The gunslinger has started slow out of the gate to begin the year, but has shown the tools to take over a game at any point.
"Herbert's a big, strong, physical quarterback who's athletic, who can make plays with his feet, make plays with his arm, got all the arm talent in the world," OLB Bradley Chubb said. "... He's continued to show it year in and year out. I know they haven't had the team success that they wanted, but I feel like he's a great quarterback, and if you're not careful, he could do a lot of damage."
On the defensive side, Los Angeles has multiple stars at different levels. Run defense has been the group's specialty, heading into Week 3 ranked seventh in rushing yards allowed per game (86.5).
"They've got some real talent," QB Josh Allen said. "Khalil Mack's one of the best pass rushers in the last 20 or so years. And I think he still plays at a very high level. I think their DBs are savvy. Derwin James is one of the better safeties in the league. And he's not afraid to come down and lay the boom. I know that all too well, going back to my first start.
"So yeah, they throw a lot of different looks at you. You got to be ready for a lot of different things. And we got to play our best football, put our best foot forward, and try to win the game on Sunday. "
The Chargers have a tough road ahead even after taking on the Bills in Week 3. They'll play five 2025 playoff teams in their next six games, with the only outlier being a duel against the 2-0 Kansas City Chiefs.
With its opponent looking to right the ship, it'll be on Buffalo to defend Highmark Stadium when the second game in the building's history kicks off on Sunday.
"I hope we're desperate and our backs are against the wall," Brady said. "It's the NFL; every team, every single week you're gonna have to be at your best football. And we're gonna get their best, as we should. They've got a great roster, great coaching staff. Coach Jim Harbaugh has his guys ready to go. And it's my job to make sure that my guys are ready to just do their job and not have to do anything more, nothing less."
Injury updates
Joe Brady did not have any additional updates on DL Ed Oliver after he suffered a hip injury in warmups prior to the Week 2 matchup against the Detroit Lions. He did not participate in Wednesday's practice.
However WR DJ Moore was back at practice and wore a non-contact jersey. Moore was a limited participant, getting back on the field for the first time since exiting last week's game in the second quarter with a shoulder injury.
"It felt great. Still got to go through some things, but we're going to be good," Moore said. "… Probably like two days after the game, I was like, 'All right, this is feeling better,' and we're going to give it a go… I just go out there and just be me. If I can go, I'm going to go; we're going to see."
DL T.J. Sanders missed the first two games of the regular season, also absent from practice on Wednesday. Brady shared with the media that the 23-year-old had an appendectomy on Tuesday night, which kept him out of practice, but was "close" to playing in Week 2 with his knee injury, and has yet to confirm his status for Sunday's game.
WR Keon Coleman also did not participate on Wednesday with an ankle injury. DB Jordan Hancock (hamstring) and G Ar'maj Reed-Adams (elbow) were both limited.
"There's going to be some things injury-wise that we're going to have to evaluate throughout the week. There'll be guys that are not going to be out there at practice today, that we still feel good about them playing in the game this week," Brady added. "So we'll just kind of see what it looks like throughout the week, and go from there."
Scroll to see the best photos from the Buffalo Bills practice at the Kaleida Health Performance Center in Orchard Park, NY.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at the Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
Buffalo Bills Week 3 Practice, September 23, 2026 at Kaleida Health Performance Center.
