Bills head coach Sean McDermott told WGR550 that defensive end A.J. Epenesa (concussion) and linebacker Shaq Thompson (hamstring) will be out for Sunday's game against the Miami Dolphins.
Multiple players did not practice on Wednesday but were upgraded to limited for Thursday's practice — defensive end Joey Bosa (wrist), running back James Cook (ankle), cornerback Taron Johnson (groin) and defensive tackle DaQuan Jones (calf).
Cornerback Christian Benford (groin) was limited for Wednesday but did not practice on Thursday.
Wide receiver Joshua Palmer, who has missed two games with a knee/ankle injury, was limited for Wednesday and Thursday's practices.
McDermott said Jones, Palmer, Johnson and Benford will be limited for Friday's practice and questionable for Sunday's game in Miami.
DOWNLOAD THE BILLS APP FOR THE LATEST BILLS NEWS AND UPDATES
Post-practice update:
Scroll to see the best photos as the Buffalo Bills prepare for Week 10 of the NFL season at the Buffalo Bills Training Center.
Keleki Latu (83), Josh Allen (17), Jackson Hawes (85). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Travis Clayton (67). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Alec Anderson (70). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Alec Anderson (70). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Connor McGovern (66), Ryan Van Demark (74), Kendrick Green (53). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Jordan Phillips (52). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Kingsley Jonathan. Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Brandon Codrington (29). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Javon Solomon (56). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Greg Rousseau (50). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Spencer Brown (79). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
DaQuan Jones (92). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
DaQuan Jones (92). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Dion Dawkins (73), Kendrick Green (53). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Dion Dawkins (73). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Ryan Van Demark (74). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Dion Dawkins (73). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
James Cook (4). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Connor McGovern (66), Josh Allen (17). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Ryan Nielsen, Zion Logue (93). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Ryan Nielsen, Deone Walker (96). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Joshua Palmer (5). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Keon Coleman (0). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
James Cook (4). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Dalton Kincaid (86), Rob Boras. Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Larry Ogunjobi (99). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Brandon Codrington (29). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Greg Rousseau (50). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
/b71/. Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Greg Rousseau (50). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Larry Ogunjobi (99). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Maxwell Hairston (31). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Gabe Davis (13). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Keon Coleman (0). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Kyle Shurmur, Gabe Davis (13). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
. Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Elijah Moore (18). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Ryan Van Demark (74), Kendrick Green (53). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Alec Anderson (70), Ryan Van Demark (74). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Ty Johnson (26). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Reggie Gilliam (41). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Joshua Palmer (5). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Keleki Latu (83), Josh Allen (17). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Josh Allen (17), Jackson Hawes (85). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Josh Allen (17), Mitchell Trubisky (11), Shane Buechele (6). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Gabe Davis (13). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Ty Johnson (26). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Jackson Hawes (85), Josh Allen (17). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Joshua Palmer (5). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Shaq Thompson (45), Baylon Spector (54). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Dawson Knox (88). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Matt Milano (58). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
James Cook (4). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Joe Andreessen (44). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Dalton Kincaid (86). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Terrel Bernard (8). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Reggie Gilliam (41). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Stephen Gosnell (89). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Khalil Shakir (10). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Khalil Shakir (10). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Joshua Palmer (5). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Joshua Palmer (5). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Tommy Akingbesote (71). Jordan Phillips (52). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Curtis Samuel (1). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Elijah Moore (18). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Zion Logue (93), Phidarian Mathis (72). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Zion Logue (93), Phidarian Mathis (72), Ryan Nielsen. Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Kelly Skipper, James Cook (4), Ray Davis (22). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Ray Davis (22), Ty Johnson (26), James Cook (4). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Ty Johnson (26), James Cook (4). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Ray Davis (22). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
James Cook (4), Ty Johnson (26). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Ty Johnson (26). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Te'Cory Couch (33). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Tyrell Shavers (14). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Khalil Shakir (10), Gabe Davis (13). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Dion Dawkins (73). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
Dion Dawkins (73). Buffalo Bills Week 10 Practice, November 06, 2025 at Buffalo Bills Training Center.
