Top 10 reasons you won't want to miss Buffalo's showdown in the South

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10. The boys are back in town

For Bills Head Coach Sean McDermott, General Manager Brandon Beane and Bills players Mike Tolbert, Joe Webb and Leonard Johnson, Buffalo's Week 2 road trip will be a blast from the past. Each having spent time with the organization, the Bills boys will see many familiar faces this weekend.

9. Carolina on the mind

Despite the homecoming, Head Coach Sean McDermott and the Bills have one thing on their mind – working as a team to get the job done.

"It's the respect for what it takes to win, and the development that has to happen every day, and the work you have to put in every day, the focus," said McDermott. "That's really where my focus is and I hope our focus is as a team."

Check out photos of the Buffalo Bills traveling in style! Best Dressed is presented by BENRUS.

8. Who wore it best?

Not only do quarterbacks Tyrod Taylor and Cam Newton have similar play style, they're also known for their fashion sense. Throughout their time in the League, both Taylor and Newton have gained national attention for their unique game day looks. Each earning a spot on SI's 2017 Fashionable 50 list, the two will square off in more than one way this weekend. 

Check out fan photos from the 2017 home opener vs. the Jets

7. No one circles the wagons like…Bills fans

Bills fans are the best fans and that's evident even when the team is on the road. With Bills Backers Chapters all over North Carolina, Buffalo's presence will be strong and ready to represent on Sunday. Time to circle the wagons.

6. Bills bring the shade

With 110 yards rushing in Buffalo's season opener against the Jets, it's clear that Shady McCoy is picking up right where he left off in 2016. One of the top rushers in the NFL through Week 1, McCoy is looking primed for another standout performance. Although Carolina's stout defensive line may pose a challenge for the run game, don't be surprised if McCoy brings the shade to sunny Charlotte.

5. Clay all day

Bills tight end Charles Clay is certainly no stranger to the end zone. Since Week 14 of the 2016 season, Clay has managed five receiving touchdowns. Tied with Green Bay's Jordy Nelson for first in the NFL in the category, Clay is just getting started.

4. Minimizing the threatLike Buffalo's own signal caller, the Carolina Panthers have a dual threat in quarterback Cam Newton. Known for his ability to make plays with his legs, Newton can be dangerous if given running room. However, running room is not something the Bills defense is willing to allow. Giving up just 38 yards on the ground in Week 1, the Bills 'D' is currently ranked second in total defense. It could be a long day for Newton and crew.

3.  Buffalo's dynamic duo

Bills safeties Jordan Poyer and Micah Hyde put on quite a show during their regular season debut. The newcomers appeared right at home in Buffalo's secondary, making big plays at critical times. The dynamic duo will look to make their mark against a productive Carolina offense.

Check out photos of memorable Bills versus Panthers games through the years.

2.  Third time's a charm

The Bills don't play the Panthers often, but when they do, they've had success. Trying for their third straight road win against Carolina, the Bills are up for the challenge.

1. Going for two

Coming off a Week 1 win, the Bills have their sights set on getting their second. Not only would a victory mark Buffalo's first 2-0 start since 2014, it would also make Head Coach Sean McDermott the first coach in Bills history to win his first two games.

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