Top 3 Individual Matchups
1 – Cordy Glenn vs. Khalil MackThe Raiders defensive scheme is designed to get Mack in one-on-ones in pass rushing situations. Buffalo's offensive staff will need to provide help at times for Glenn as few offensive tackles can handle Mack one-on-one. Last year, Mack had seven tackles, a sack, a forced fumble and fumble recovery and a pass breakup.
2 – Jerry Hughes vs. Donald PennHughes was not credited with a single tackle in last year's game against Oakland despite playing 43 snaps. You can rest assured Hughes will be motivated to change that storyline in his rematch with Penn.
3 – Tre'Davious White vs. Amari CooperThere's a decent chance that White follows Cooper wherever he goes if E.J. Gaines doesn't play Sunday. White won't be intimidated by Cooper having faced him for two years in college, but he does consider Cooper one of the sharpest route runners he's ever faced. And Cooper is riding high after an 11-catch, 210-yard outing last week with a pair of TDs.
Check of photos of memorable Buffalo Bills versus Oakland Raiders games through the years.
Top 2 Bills Advantages
Good advantage – Run gameBuffalo's run game got back on track last week. Tyrod Taylor got back to being a good rushing complement to LeSean McCoy and Oakland's run defense is still trying to round into form, ranked 19th in the league.
Best advantage – Run defenseThe Bills seventh-ranked run defense should fare well against an Oakland rushing attack that doesn't have their hammer in Marshawn Lynch. The power back is serving a one-game league-imposed suspension for bumping an official. Even with Lynch this season the Raiders are managing less than 93 rushing yards per game.
Bills Number 1 Must
Win on third down (defense)Buffalo's offense should fare well against one of the league's worst third down defenses, but the Bills defense has to do well in getting off the field against Derek Carr and the Raiders high-powered attack. Oakland has had a high rate of three-and-outs this season, but last week against the Chiefs they had just one three-and-out on 10 possessions. If Buffalo can hold Oakland under 40 percent on third down conversions they stand a good chance of winning the game.
Marshawn-lessThe Raiders will be without Marshawn Lynch after he made contact with an official in last week's game. Lynch is serving a one-game suspension. Playing for his hometown team hasn't been as productive as hoped. He's averaging just 3.7 yards per carry and has just a pair of touchdowns.
Stepping in to fill the void will be Jalen Richard and DeAndre Washington. Oakland also elevated Elijah Hood from their practice squad. Richard has seen more time and is averaging 4.5 yards per carry.
Slotting CooperAmari Cooper had a breakout game with 11 catches for 210 yards and a pair of touchdowns last week. In an effort to get him more opportunities to make plays, the Raiders offensive staff had him work out of the slot more than ever.
By the end of the game, Cooper had made six of his 11 receptions running out of slot alignments. According to @SportsradarUS, Cooper had never caught more than three passes out of the slot in a game.
Nicked up on the cornerThe Raiders have some cornerbacks battling injuries this week, including starter David Amerson. Amerson is dealing with a foot injury and his backup rookie Gareon Conley is battling a shin injury. Neither player practiced on Wednesday.
If neither player can go on Sunday, Oakland will be down to four healthy cornerbacks on their roster. Veteran Sean Smith would be the expected fill-in starter if Amerson and Conley cannot play.
Comeback CarrIt's hard to keep Derek Carr from making plays in the passing game, but the Bills have to play right to the end after watching Oakland's quarterback orchestrate a comeback last year against Buffalo that wiped out a 15-point deficit. The Bills were up 24-9 midway through the third quarter in last year's game at Oakland, but Carr led four unanswered touchdown drives to lift the Raiders to 14-point victory.
Carr led a game-winning come from behind drive in the fourth quarter last week against Kansas City marking the 12th time he's done that since 2015, more than any other quarterback in the league.
Helping Carr of late is play action. Prior to last week's game, the Raiders had just nine plays in which they made use of play action. Oakland used play action nine times alone in their game against the Chiefs.
Trouble with takeawaysThe Raiders defense hasn't been too effective in forcing turnovers. They managed to collect just five in seven games. All of those takeaways have come via fumble recoveries as Oakland is the only team in the league that has yet to record an interception. They've gone seven straight games without a pick making it the longest streak to start a season in the NFL since 1950.
Buffalo has committed the fewest turnovers through their first six games in team history (3).
Quote of the week"This team the way it's made up, the leaders, I think we have a great core to push over our message that 'Yes, (last week) was a great win, but there's also some things that can be corrected,' and moving forward, we have to be better at those things for us to continue to keep winning. It's definitely a different team, new coaches, [a] different feel in the locker room. You just have to take it one game at a time and that's more so our focus this year."
--QB Tyrod Taylor
Stat of the WeekThe Bills have scored at least 20 points in 12 consecutive home games, the longest active streak of its kind in the NFL. The Bills are 4-0 this season overall when scoring 20 points.
Milestones in reachStephen Hauschka needs three points to reach 900 in his career and one 50-yard field goal to set the NFL record for most consecutive 50-yard plus attempts made (13).
Jerry Hughes needs one sack for 40 in his career.
Mike Tolbert needs one rushing touchdown to become the fifth active player to have 35 rushing touchdowns and 10 receiving touchdowns.
Kyle Williams needs one start to have the second-most career starts by a Bills defensive lineman in team history, passing Fred Smerlas (152).
Final noteEach of the last six meetings between the Bills and Raiders has been won by the home team.