| 2021-12-01 | Bills coaches address their plans for the secondary after losing Tre'Davious White |
| 2021-12-01 | Top 5 storylines to follow for Bills vs. Patriots | Monday Night Football |
| 2021-12-01 | Tre'Davious White thanks Bills Mafia for raising more than $100K for his hometown |
| 2021-12-02 | Bills sign Greg Stroman to the practice squad |
| 2021-12-02 | Terrell Owens announced as the Bills Legend of the Game | Week 13 |
| 2021-12-03 | Bills players explain why turnovers will decide Monday night’s winner + other notes on Bills vs. Patriots |
| 2021-12-03 | 7 things to watch for in Bills vs. Patriots | Week 13 |
| 2021-12-04 | ‘Working while you wait’ | How Dane Jackson is preparing for his primetime debut |
| 2021-12-04 | Bills list three players as questionable for Bills vs. Pats | Week 13 |
| 2021-12-04 | What Bills fans need to know about the 2021 AFC playoff race | Week 13 |
| 2021-12-05 | NFL analysts | Bills vs. Patriots game predictions | Monday Night Football |
| 2021-12-06 | Top 10 reasons to be excited for Bills vs. Patriots on Monday Night Football |
| 2021-12-06 | Bills place A.J. Klein on the reserve/COVID-19 list; Eli Ankou and Joe Giles-Harris elevated for Bills-Patriots game |
| 2021-12-06 | Marquez Stevenson, Isaiah McKenzie headline the Bills inactives list | Week 13 |
| 2021-12-07 | Bills vs. Patriots | How to watch, stream, and listen | Week 13 |
| 2021-12-07 | Patriots 14, Bills 10 | Game recap, highlights & photos |
| 2021-12-07 | Bills acknowledge missed opportunities against the Patriots |
| 2021-12-07 | Top 3 things we learned from Bills vs. Patriots | Week 13 |
| 2021-12-07 | Harrison Phillips selected as Buffalo’s Walter Payton Man of the Year nominee for second consecutive year |
| 2021-12-08 | Top 5 storylines to follow for Bills vs. Buccaneers |
| 2021-12-08 | Bills special teams stalwart Mark Pike passes away |
| 2021-12-09 | What will it take to stop familiar foe Tom Brady and the Buccaneers offense |
| 2021-12-09 | Bills and Sabres announce partnerships with Seneca Gaming |
| 2021-12-10 | 6 things to watch for in Bills at Buccaneers | Week 14 |
| 2021-12-10 | Star Lotulelei and Tommy Sweeney ruled out for Bills at Buccaneers | Week 14 |
| 2021-12-10 | Corona Hard Seltzer Block Party |
| 2021-12-11 | What Bills fans need to know about the 2021 AFC playoff race | Week 14 |
| 2021-12-11 | NFL analysts | Bills at Buccaneers game predictions | Week 14 |
| 2021-12-11 | Bills activate Jon Feliciano from injured reserve; 3 players elevated for Sunday’s game |
| 2021-12-12 | Kyle Brandt pumps up Bills Mafia in advance of the Tampa Bay game |
| 2021-12-12 | Zack Moss, Cody Ford headline inactive list for Bills at Buccaneers | Week 14 |
| 2021-12-12 | Bills at Buccaneers | How to watch, stream, and listen | Week 14 |
| 2021-12-13 | Buccaneers 33, Bills 27 | Game recap, highlights & photos |
| 2021-12-13 | Where the Bills stand in the 2021 AFC playoff picture after Week 14 |
| 2021-12-13 | Top 3 things we learned from Bills at Buccaneers | Week 14 |
| 2021-12-13 | Bills players believe unity formed in Tampa will pay dividends moving forward |
| 2021-12-13 | Josh Allen day-to-day with a foot sprain |
| 2021-12-15 | Top 5 storylines for Bills vs. Panthers | Week 15 |
| 2021-12-15 | Josh Allen limited on Wednesday, A.J. Klein activated from reserve/COVID-19 list |
| 2021-12-15 | Mark Maddox named Bills Legend of the Year |
| 2021-12-15 | 5 takeaways from Josh Allen and Jordan Poyer's Wednesday press conferences | Week 15 |
| 2021-12-16 | Scott Chandler to return as the Bills Legend of the Game | Week 15 |
| 2021-12-17 | 5 things to watch for in Bills vs. Panthers | Week 15 |
| 2021-12-17 | Josh Allen expected to start vs. Carolina plus other injury updates from Sean McDermott |
| 2021-12-18 | What Bills fans need to know about the 2021 AFC playoff race | Week 15 |
| 2021-12-18 | NFL analysts | Bills vs. Panthers game predictions | Week 15 |
| 2021-12-18 | Bills great Harry Jacobs passed away at the age of 84 |
| 2021-12-19 | Bills place Jon Feliciano on the reserve/COVID-19 list; Jacob Capra elevated from the practice squad |
| 2021-12-19 | Zack Moss, AJ Epenesa inactive; Star Lotulelei returns to the lineup |
| 2021-12-19 | Bills vs. Panthers | How to watch, stream, and listen | Week 15 |
| 2021-12-19 | Bills 31, Panthers 14 | Game recap, highlights & photos |
| 2021-12-20 | Top 3 things we learned from Bills vs. Panthers | Week 15 |
| 2021-12-20 | Bills eye rematch against New England + 3 other notes from the victorious locker room | Week 15 |
| 2021-12-20 | Where the Bills stand in the AFC playoff picture after Week 15 |
| 2021-12-20 | Bills place A.J. Epenesa on the reserve/COVID-19 list |
| 2021-12-21 | Bills coaches preach this as team prepares for second matchup against the New England Patriots |
| 2021-12-21 | Buffalo Bills Foundation donates $50,000 to the Rural Outreach Center |
| 2021-12-21 | Bills place Cole Beasley on the reserve/COVID-19 list |
| 2021-12-22 | Bills announce updated vaccination policy for Highmark Stadium |
| 2021-12-22 | Bills sign defensive end Breeland Speaks to the practice squad |
| 2021-12-22 | Top 6 storylines for Bills at Patriots | Week 16 |
| 2021-12-22 | Bills lean on player-driven leadership to prepare for rematch against the Patriots |
| 2021-12-23 | Stefon Diggs and Dion Dawkins to represent the Bills in the 2022 Pro Bowl |
| 2021-12-23 | Bills activate LB Tyrel Dodson off the reserve/COVID-19 list |
| 2021-12-23 | Two members of Bills Mafia to be honored with this award on Christmas Day |
| 2021-12-23 | How Emmanuel Sanders & his Bills teammates are giving back this holiday season |
| 2021-12-23 | Stefon Diggs reflects on joining his brother Trevon Diggs in the 2022 Pro Bowl |
| 2021-12-24 | 6 things to watch for in Bills at Patriots | Week 16 |
| 2021-12-24 | Bills add Gabriel Davis and Cody Ford to the reserve/COVID-19 list |
| 2021-12-24 | Bills list Star Lotulelei as questionable for Bills at Patriots | Week 16 |
| 2021-12-24 | Bills elevate WR Isaiah Hodgins and OL Bobby Hart for Bills at Patriots | Week 16 |
| 2021-12-25 | Top 5 players to watch in Bills at Patriots | Week 16 |
| 2021-12-25 | What Bills fans need to know about the 2021 AFC playoff race | Week 16 |
| 2021-12-25 | Bills activate Dion Dawkins; Lotulelei ruled out for Bills at Pats |
| 2021-12-26 | NFL game predictions for Bills at Patriots | Week 16 |
| 2021-12-26 | Matt Breida headlines Bills inactives list for Bills at Pats | Week 16 |
| 2021-12-26 | Bills at Patriots | How to watch, stream, and listen | Week 16 |
| 2021-12-26 | Bills 33, Patriots 21 | Game recap, highlights & photos |
| 2021-12-26 | Where the Bills stand in the AFC playoff picture after Week 16 |
| 2021-12-27 | How the ‘next man up’ mentality helped the Bills defeat the Patriots |
| 2021-12-27 | Top 3 things we learned from Bills at Pats | Week 16 |
| 2021-12-27 | How Bills fans can win tickets to Super Bowl LVI |
| 2021-12-27 | Josh Allen, Bills earn nationwide respect with statement win | Week 16 |
| 2021-12-27 | Bills announce a series of roster moves |
| 2021-12-28 | Sean McDermott backs coordinators for head coaching opportunities |
| 2021-12-28 | From NYC to Buffalo | Jeremiah Ranzie is the Bills' Season Ticket Member of the month for December |
| 2021-12-28 | Subtle adjustments, creativity help Brian Daboll evolve Buffalo’s offense for the stretch run |
| 2021-12-29 | Top 5 storylines to follow for Bills vs. Falcons | Week 17 |
| 2021-12-29 | Bills activate Cole Beasley, Gabriel Davis, Jon Feliciano and A.J. Epenesa from reserve/COVID-19 list |
| 2021-12-29 | How the Bills can clinch a 2021 AFC playoff spot | Week 17 |
| 2021-12-29 | Madden’s influence on the Bills + other things we learned from the locker room |
| 2021-12-30 | Josh Allen named a finalist for NFL's 2021 Art Rooney Sportsmanship award |
| 2021-12-30 | Brian Moorman set to return as the Bills Legend of the Game |
| 2021-12-30 | Bills activate Cody Ford and Cam Lewis from reserve/COVID-19 list |
| 2021-12-31 | 5 things to watch for in Bills vs. Falcons | Week 17 |
| 2021-12-31 | Bills list Ed Oliver and Emmanuel Sanders as questionable for Bills vs. Falcons | Week 17 |
