The Bills head to Houston to take on the Texans in Week 6 of the 2018 Season.
The Bills travel west to Indianapolis to take on the Colts in a rematch of last year's 'snow game' OT thriller.
The Bills return home to New Era Field to take on Marcus Mariota and the Tennessee Titans in Week 5.
The Bills head to Green Bay to take on Aaron Rodgers and rest of the Packers in Week 4 of the 2018 Season.
In Week 3, the Bills travel west to take on the Minnesota Vikings at US Bank Stadium in Minneapolis.
Rookie QB Josh Allen makes his starting debut as the Bills gear up for their Home Opener against the Los Angeles Chargers in Week 2 of the 2018 Season.
QB Nate Peterman and the Bills head south to take on the Baltimore Ravens in Week 1 of the 2018 Season.