| 2021-09-01 | Bills sign 15 players to the 2021 practice squad |
| 2021-09-01 | Bills re-sign long-snapper Reid Ferguson |
| 2021-09-01 | 6 things we learned from GM Brandon Beane about the Bills 2021 roster |
| 2021-09-02 | 4 things we learned from Sean McDermott heading into Week 1 of the NFL season |
| 2021-09-04 | What They’re Saying | 7 fantasy football opinions on the Bills heading into the 2021 season |
| 2021-09-07 | Frontier's Rich Gray and Attica's Jeff Cusmano earn ADPRO Sports High School Coach of the Week honors | Week 1 |
| 2021-09-07 | Top 5 storylines to follow for Bills vs. Steelers | Week 1 |
| 2021-09-07 | Bills name eight captains for the 2021 season |
| 2021-09-07 | Bills sit among the NFL's best teams in Week 1 power rankings | News & Notes |
| 2021-09-08 | 'This is my new home' | Why Stefon Diggs was thrilled to be selected as a Bills captain |
| 2021-09-08 | Bills players understand that the time to win is now |
| 2021-09-09 | What they're saying | National analysts make these predictions for the Bills 2021 season |
| 2021-09-09 | Patti Thomas unveils her collection of paintings | Bills Today |
| 2021-09-10 | 'This business comes full circle' | How Jerry Hughes developed into the defensive line's veteran mentor |
| 2021-09-10 | Star Lotulelei out for Bills vs. Steelers |
| 2021-09-10 | Brandon Beane, Dion Dawkins, & Matt Haack aim to raise money and awareness for these causes | Bills Today |
| 2021-09-10 | 6 things to watch for in Bills vs. Steelers | Week 1 |
| 2021-09-11 | NFL analysts | Bills vs. Steelers game predictions | Week 1 |
| 2021-09-12 | Zack Moss, Boogie Basham headline list of Bills inactives | Week 1 |
| 2021-09-12 | Bills vs. Steelers | How to watch, stream and listen | Week 1 |
| 2021-09-12 | Steelers 23, Bills 16 | Game recap, highlights & photos |
| 2021-09-13 | ‘This will be a pivotal moment’ | Bills players remain confident despite the loss |
| 2021-09-13 | Top 3 things we learned from Bills vs. Steelers | Week 1 |
| 2021-09-13 | 'Where else could you be?' | Inside Bills Mafia's raucous return to Highmark Stadium |
| 2021-09-14 | Why the Bills defensive line rotation was a bright spot in Week 1 |
| 2021-09-14 | Randolph's Brent Brown & Brighton's Steve Lian earn high school coach of the week honors | Week 2 |
| 2021-09-14 | Bills remain in the top 10 of Week 2 power rankings | Bills Today |
| 2021-09-14 | Bills announce stadium vaccination policy in compliance with ECDOH directive |
| 2021-09-15 | Top 4 storylines to follow for Bills at Dolphins | Week 2 |
| 2021-09-15 | Sean McDermott announced Gabriel Davis will miss Wednesday's practice | Bills Today |
| 2021-09-15 | Bills look to solve this problem heading into Sunday’s Miami game |
| 2021-09-16 | Corona Hard Seltzer announces new, multi-year partnership with the Buffalo Bills |
| 2021-09-16 | Josh Allen and Stefon Diggs grace the cover of Sports Illustrated for Kids | Bills Today |
| 2021-09-16 | Bills fans can support Huddle for Hunger week starting September 20 |
| 2021-09-16 | How Bills fans can enter the NFL's Fan of the Year contest |
| 2021-09-17 | Why Bills rookie Greg Rousseau is excited to play in Miami again |
| 2021-09-17 | Two Bills coaches land on SI.com’s potential future head coaches list | Bills Today |
| 2021-09-17 | 8 things to watch for in Bills at Dolphins | Week 2 |
| 2021-09-17 | Three Bills players listed as questionable for Bills at Dolphins |
| 2021-09-18 | NFL analysts | Bills at Dolphins game predictions | Week 2 |
| 2021-09-19 | Gabriel Davis, Star Lotulelei active; Efe Obada inactive | Bills at Dolphins |
| 2021-09-19 | Bills at Dolphins | How to watch, stream and listen | Week 2 |
| 2021-09-19 | Bills 35, Dolphins 0 | Game recap, highlights & photos |
| 2021-09-20 | Zack Moss plays with a heavy heart + other notes from the Bills win in Miami |
| 2021-09-20 | Top 3 things we learned from Bills at Dolphins | Week 2 |
| 2021-09-20 | Josh Allen hits multiple milestones, leaves room for improvement in win over the Miami Dolphins |
| 2021-09-20 | Leslie Frazier earns national 'Coach of the Week' recognition | Bills Today |
| 2021-09-20 | Buffalo Bills welcome Fusion Digital as Acronis #CyberFit Delivery Partner |
| 2021-09-21 | Salamanca's Chad Bartoszek & Wayne's Dave Marean earn high school coach of the week honors | Week 3 |
| 2021-09-21 | Anatomy of a shutout | Inside the Bills' dominant defensive outing vs. Miami |
| 2021-09-21 | Bills fans can vote for Greg Rousseau to win this NFL rookie of the week award | Bills Today |
| 2021-09-21 | Bills peak in the top 5 of this week's NFL power rankings |
| 2021-09-22 | Bills sign offensive lineman Bobby Hart to practice squad |
| 2021-09-22 | Top 7 storylines to follow for Bills vs. Washington | Week 3 |
| 2021-09-22 | Sean McDermott announces Star Lotulelei will not practice on Wednesday | Bills Today |
| 2021-09-22 | Seven former Bills land on the Pro Football Hall of Fame Class of 2022 nomination list |
| 2021-09-23 | Why A.J. Epenesa looks like a different player in 2021 |
| 2021-09-23 | Bills, Giants & Jets partner with NY State on vaccine incentive program |
| 2021-09-24 | Taron Johnson is establishing a playmaking role on the Bills defense |
| 2021-09-24 | Bills welcome Delta Sonic as official car wash partner |
| 2021-09-24 | 6 things to watch for in Bills vs. Washington | Week 3 |
| 2021-09-24 | Emmanuel Sanders named Week 3 NFLPA community MVP |
| 2021-09-24 | Levi Wallace, Dane Jackson listed as questionable | Week 3 |
| 2021-09-24 | Lorenzo Alexander + 30 Bills legends set to return for Sunday's game | Bills Today |
| 2021-09-25 | Matt Milano on NFL's 10 most underappreciated players list | Bills Today |
| 2021-09-25 | Will Sunday mark Josh Allen's break out fantasy football game in 2021? | Bills Today |
| 2021-09-25 | NFL analysts | Bills vs. Washington game predictions | Week 3 |
| 2021-09-26 | Matt Breida, Efe Obada headline Buffalo's inactive list | Bills vs. Washington |
| 2021-09-26 | Bills vs. Washington | How to watch, stream, and listen | Week 3 |
| 2021-09-26 | Bills 43, Washington 21 | Game recap, highlights & photos |
| 2021-09-27 | Top 3 things we learned from Bills vs. Washington | Week 3 |
| 2021-09-27 | This Bills position group played the role of unsung heroes in win over Washington |
| 2021-09-27 | Bills rank as the NFL's co-leaders in point differential + more numbers from Week 3 |
| 2021-09-27 | How Bills fans can vote for Josh Allen to win this weekly NFL award | Bills Today |
| 2021-09-28 | 'It was special' | How the Bills offense rallied around Brian Daboll vs. Washington |
| 2021-09-28 | Avon's Andy Englert & Will South's Kraig Kurzanski earn high school coach of the week honors | Week 4 |
| 2021-09-28 | Bills move up in the latest NFL power rankings | Bills Today |
| 2021-09-29 | Josh Allen named AFC Offensive Player of the Week for the seventh time |
| 2021-09-29 | Top 5 storylines to follow for Bills vs. Texans | Week 4 |
| 2021-09-30 | Bills are determined to keep their focus solely on the Texans |
| 2021-09-30 | Stefon Diggs excited for his younger brother's hot start to the NFL season | Bills Today |
| 2021-09-30 | Kyle Williams to be inducted into the Louisiana Sports Hall of Fame | Bills Today |
| 2021-09-30 | Meet the Clines | Bills Season Ticket Members of the month |
| 2021-09-30 | A look back at LeSean McCoy's career in Buffalo | Bills Today |
| 2021-09-30 | Eric Moulds will return as the Bills Legend of the Game this Sunday |
