The Buffalo Bills are 1.5-point underdogs in Sunday's matchup against the Kansas City Chiefs in Highmark Stadium. The game will kick off at 4:25 pm on CBS.
Here are some additional notes for this week's game:
- This is the 10th meeting between Josh Allen and Patrick Mahomes
- The Bills are 1 of 3 teams to beat Kansas City in four straight regular season games since 2013 (Titans - 4 games from 2014-2021; Broncos - 5 games from 2013-2015)
- Bills are 3-4 against teams with a winning record since 2024
- Chiefs are on a three-game winning streak
- Chiefs are 1-2 on the road in 2025
The Bills are rare home underdogs on the moneyline but not by much. Buffalo has been a dog in front of the Orchard Park crowds only five times since 2020 and have come out with a 4-1 SU mark. I see Buffalo winning on a last-second field goal.
Score prediction: Bills 27, Chiefs 24
This is the game of the week. The Chiefs have won three straight, while the Bills blew out Carolina last week coming off their bye. The Buffalo running game clicked last week, but they will need more from Josh Allen in this one. I think they get it as Allen wins a shootout with Patrick Mahomes. This game will live up to the billing.
Pick: Bills 35, Chiefs 34
Josh Allen is 4-1 against Patrick Mahomes in the regular season, but 0-4 in the playoffs. Unfortunately for the Bills, Mahomes will be viewing this one as a game with playoff-caliber stakes.
Florio's pick: Chiefs 30, Bills 27.
Simms's pick: Chiefs 27, Bills 24.
The Chiefs' offense is hitting on all cylinders and the same is going for the Bills after their Week 7 bye. This should live up to instant high-scoring classic expectations, but in the end Kansas City has a better overall defense ready to deliver in key situations with Patrick Mahomes putting pressure on Josh Allen to keep answering.
Pick: Chiefs win 34-31 and cover the spread.
This is a tough stretch for the Chiefs, with road games at Buffalo and Denver, games that will become more important in the race for AFC playoff seeding. By now you know the trend, Allen is 4-1 S/U in head-to-head regular-season matchups against Mahomes. The Chiefs, however, have found a new gear and are equipped to win this game on the road. The Bills are 4-4 S/U as a home underdog since 2019, so this really is a toss-up.
Pick: Chiefs 28, Bills 24
Scroll to see the best photos as the Buffalo Bills prepare for Week 9 of the NFL season at the Buffalo Bills Training Center. This gallery is presented by ECMC.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Gabe Davis (13). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
James Cook (4). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Alec Anderson (70). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Mitchell Trubisky (11). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Gabe Davis (13). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Keon Coleman (0). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Joey Bosa (97). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Spencer Brown (79). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Joey Bosa (97). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Spencer Brown (79). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Gabe Davis (13). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
David Edwards (76), Mitchell Trubisky (11), Gabe Davis (13). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Alec Anderson (70). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Elijah Moore (18). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Gabe Davis (13). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Gabe Davis (13). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Gabe Davis (13), Adam Henry. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Tommy Akingbesote (71). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Larry Ogunjobi (99). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Larry Ogunjobi (99). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Jordan Phillips (52). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Joey Bosa (97). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Joey Bosa (97). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Tommy Akingbesote (71). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Sean McDermott. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Phidarian Mathis (72), Deone Walker (96). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Phidarian Mathis (72). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Jordan Phillips (52), Tommy Akingbesote (71), Jason Rebrovich. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Dalton Kincaid (86). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Jackson Hawes (85). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Jackson Hawes (85). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Shane Buechele (6). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Jahmile Addae, Maxwell Hairston (31). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Baylon Spector (54), Joe Andreessen (44), Jimmy Ciarlo (35), Keonta Jenkins (49). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Al Holcomb. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
James Cook (4). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Matt Milano (58). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Terrel Bernard (8). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Dorian Williams (42), Matt Milano (58)m Keonta Jenkins (49). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Ty Johnson (26). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Sean McDermott. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Chase Lundt (77). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Ty Johnson (26). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Keon Coleman (0). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Keon Coleman (0). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Gabe Davis (13). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Gabe Davis (13). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Mitchell Trubisky (11). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Jordan Poyer (21). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Ja'Marcus Ingram (46), Tyrell Shavers (14). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Christian Benford (47), Keon Coleman (0). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Tre'Davious White (27), Keon Coleman (0). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Gabe Davis (13). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Alec Anderson (70). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Nick Broeker (63), Tommy Akingbesote (71). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Phidarian Mathis (72), Sedrick Van Pran-Granger (62). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Ryan Van Demark (74). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Chase Lundt (77). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Chase Lundt (77). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Chase Lundt (77). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Keon Coleman (0). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Dalton Kincaid (86), Keleki Latu (83). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Tyrell Shavers (14). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Khalil Shakir (10). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
James Cook (4). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Jordan Poyer (21). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Michael Hoecht (55). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
James Cook (4). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
James Cook (4). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
James Cook (4). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
James Cook (4). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Ty Johnson (26). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Jordan Poyer (21). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Elijah Moore (18). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Ty Johnson (26). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Sean McDermott. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Mitchell Trubisky (11). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Tyrell Shavers (14). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Tyrell Shavers (14). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
James Cook (4). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Reggie Gilliam (41), Maxwell Hairston (31). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Jackson Hawes (85). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Khalil Shakir (10). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Dawson Knox (88). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Sean McDermott. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Dalton Kincaid (86). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Dalton Kincaid (86). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Khalil Shakir (10). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Sean McDermott. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Elijah Moore (18), Keon Coleman (0). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Joe Brady. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Elijah Moore (18), Keon Coleman (0). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Joe Brady, Milli Wilson, Dion Dawkins (73). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Joe Brady, Milli Wilson, Dion Dawkins (73). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Jeff Mazurek, Spencer Haws. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Sean McDermott. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Mitchell Trubisky (11). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Cole Bishop (24). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Maxwell Hairston (31). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Shane Buechele (6). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Connor McGovern (66), David Edwards (76). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Josh Allen (17). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Frank Gore Jr (20). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Maxwell Hairston (31), Gabe Davis (13). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Sean McDermott. Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Nick Broeker (63). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Curtis Samuel (1), Khalil Shakir (10). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Matt Prater (15). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Travis Clayton (67). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Larry Ogunjobi (99). Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
Buffalo Bills Week 9 Practice, October 29, 2025 at the Buffalo Bills Training Center.
What we're hearing on the Chiefs: One reason many of the Chiefs players love their rivalry with the Bills is how both fanbases support their team and hate the other team. "They do not like the Chiefs," QB Patrick Mahomes said of the Bills' fans. "It is a cool environment. I love playing in historic stadiums and that stadium has had so many great players play in it." Sunday's game could be the Chiefs' last appearance in Highmark Stadium. Mahomes hopes Kansas City can pull together for its first victory in Buffalo since 2020. -- Nate Taylor
What we're hearing on the Bills: Though the Bills' offense has reigning MVP Josh Allen, and RB James Cook III is off to an explosive start, questions linger about the recent struggles of the outside passing game. The defense is also dealing with injuries and will have to keep pace with a Chiefs offense that has gotten hot after Rashee Rice's return. "Anytime you're playing against a good team and a good quarterback, you have to get to play at the top of your game in order to win a football game," Allen said. "So, not that you don't go out there and try to play your best all the time, there is a heightened sense of awareness to that, of understanding who's on the other side of the football." -- Alaina Getzenberg
Stat to know: This is the 10th matchup between Mahomes and Allen, including the playoffs. Since 1950, no QBs under 30 have faced off more from different divisions. -- ESPN Research
Bold prediction: The Bills will record multiple 30-plus-yard gains on crossing routes. They run crossing routes 13% of the time, second most in the NFL, while the Chiefs -- despite having a good pass defense -- have allowed 0.77 EPA per play against targeted crossing routes (second worst). -- Walder
Fantasy nugget: Chiefs RB Kareem Hunt is set up for success with Isiah Pacheco dealing with a right MCL sprain. Hunt's nose for the end zone has kept him on the fantasy radar, scoring five total touchdowns in eight games. The Bills' defense also allows the sixth-most fantasy points per game to RBs. See Week 9 rankings. -- Moody
Betting nugget: Allen is 4-1 outright and ATS against Mahomes in the regular season, including four straight wins and covers. Read more. -- ESPN Research
Maldonado's pick: Chiefs 23, Bills 20
Moody's pick: Chiefs 32, Bills 24
Walder's pick: Bills 27, Chiefs 24
FPI prediction: KC, 58.2% (by an average of 2.6 points)
Gagnon: Bills (+2.5)
The Bills have had Kansas City's number in the regular season, so I'm confused as to why they'd be getting points at home in this spot. Buffalo lost its last home game to New England, but that works out well because it hasn't lost two consecutive home games since 2021.
O'Donnell: Chiefs (-2.5)
I hate not rolling with the Bills. They have won the last four regular-season meetings, yet they have lost each of the postseason meetings. This is going back to the playoffs in the year of 2021. So, this is one of those games where I fast-forward in my mind what could be later this season.
I'm going to flip the script and have a rolling Chiefs team get the win and cover, putting the Bills on their heels in November (which would be three losses in their last four games) and setting the table for Josh Allen to finally beat Patrick Mahomes when it really matters—in January.
Predictions
Chiefs: Hanford, Knox, Moton, O'Donnell
Bills: Davenport, Gagnon, Sobleski
Why Dan picked the Chiefs: A clear pattern has emerged between these two AFC heavyweights, with the Bills beating the Chiefs in four straight regular-season games and Kansas City eliminating Buffalo in four straight playoff matchups. I think the streak -- at least the regular-season one -- snaps this time around. The Chiefs are the only team with a top-five total offense and defense right now. Patrick Mahomes has clearly been the best QB in the NFL since Week 4. Meanwhile, shockingly, Josh Allen has the league's lowest passer rating on deep passes in 2025 (29.4, min. 15 deep attempts) and Buffalo lost at home in its only game against a team with a winning record (Patriots in Week 5). It gets worse, as the Bills will be without DT Ed Oliver, the engine of their defense, as he recovers from a torn bicep suffered in last week's win over the Panthers. The reigning MVP is capable of putting the team on his back, even against the toughest competition, but I see an advantage for the Chiefs that is too significant for me to ignore.
