| 2021-10-01 | How Matt Milano has taken his game to the next level by becoming a vocal leader |
| 2021-10-01 | 7 things to watch for in Bills vs. Texans | Week 4 |
| 2021-10-01 | Jordan Poyer and Jon Feliciano declared out for Bills vs. Texans | Week 4 |
| 2021-10-01 | Next Man Up | Bills will lean on team’s depth heading into Week 4 |
| 2021-10-02 | NFL analysts | Bills vs. Texans game predictions | Week 4 |
| 2021-10-02 | Bills elevate CB Cam Lewis |
| 2021-10-03 | CB Taron Johnson inactive; Boogie Basham set to make his NFL debut |
| 2021-10-03 | Bills vs. Texans | How to watch, stream, and listen | Week 4 |
| 2021-10-03 | Bills 40, Texans 0 | Game recap, highlights & photos |
| 2021-10-03 | Bills celebrate a shutout victory over Houston | Social Media Round-up |
| 2021-10-04 | Top 3 things we learned from Bills vs. Texans | Week 4 |
| 2021-10-04 | ‘We have a farm system here’ | Young players step up in Bills’ victory over Houston |
| 2021-10-04 | Bills lead the NFL in these 11 defensive categories + more numbers to know |
| 2021-10-05 | The Bills coaching staff wants the team to focus on this heading into Chiefs week |
| 2021-10-05 | Bennett's Steve McDuffie & East Rochester's Brian Touranjoe earn high school coach of the week honors | Week 5 |
| 2021-10-05 | Bills rise to the top of this week's NFL power rankings |
| 2021-10-06 | Tremaine Edmunds named AFC Defensive Player of the Week |
| 2021-10-06 | Top 5 storylines to follow for Bills at Chiefs | Week 5 |
| 2021-10-06 | ESPN survey highlights the Bills' use of applying analytics |
| 2021-10-06 | Sean McDermott announced these injury updates for the Bills heading into Wednesday's practice |
| 2021-10-07 | 'It’s a big game because it’s the next game' | Bills focus on the Chiefs not the narratives |
| 2021-10-07 | What they're saying | NFL analysts share their opinions on the surging Bills |
| 2021-10-08 | Why Spencer Brown’s first road start in Kansas City will be special |
| 2021-10-08 | 7 things to watch for in Bills at Chiefs | Week 5 |
| 2021-10-08 | Matt Milano, A.J. Epenesa & Taiwan Jones are questionable for Bills at Chiefs |
| 2021-10-09 | Bills sign CB Taron Johnson to a three-year contract extension |
| 2021-10-09 | NFL analysts | Bills at Chiefs game predictions | Week 5 |
| 2021-10-10 | NFL greats assess the magnitude of Sunday’s Bills-Chiefs matchup |
| 2021-10-10 | Matt Milano inactive; A.J. Epenesa active for Bills at Chiefs | Week 5 |
| 2021-10-11 | Bills at Chiefs | How to watch, stream, and listen | Week 5 |
| 2021-10-11 | Bills 38, Chiefs 20 | Game recap, highlights & photos |
| 2021-10-11 | Bills earn high praise for a big win in Kansas City | Social Media Round-up |
| 2021-10-11 | Top 3 things we learned from Bills at Chiefs | Week 5 |
| 2021-10-11 | ‘This is just another win’ | Bills players maintain perspective after beating the defending AFC champions |
| 2021-10-11 | The NFL's best scoring offense and defense resides in Buffalo | Week 5 |
| 2021-10-12 | 'Be patient' | How the Bills defense slowed down the Chiefs |
| 2021-10-12 | Albion's David Skrip and OAE's Tyler Winter earn high school coach of the week honors | Week 6 |
| 2021-10-12 | Bills remain at the top of NFL power rankings | Week 6 |
| 2021-10-13 | Rookie Greg Rousseau named AFC Defensive Player of the Week |
| 2021-10-13 | Top 5 storylines for Bills at Titans | Week 6 |
| 2021-10-13 | Bills Mafia and Josh Allen help raise $100,000 for Firebaugh High School |
| 2021-10-14 | Bills-Chiefs delivers big audience on NBC’s Sunday Night Football |
| 2021-10-14 | Sean McDermott announced Matt Milano will return to practice on Thursday |
| 2021-10-14 | Biggest surprise of the season? Dawson Knox makes this NFL.com list |
| 2021-10-15 | Decoys? Selflessness? How the Bills playmakers are willing to sacrifice for team success |
| 2021-10-15 | 7 things to watch for in Bills at Titans | Week 6 |
| 2021-10-15 | ‘Bills by the Numbers’ podcast is available now |
| 2021-10-15 | Jaquan Johnson is making an impact on and off the field |
| 2021-10-16 | How Bills fans can bid on exclusive autographed merchandise this weekend |
| 2021-10-16 | Why Brett Favre and Drew Brees think the Bills are set up for success |
| 2021-10-16 | Sean McDermott offers an optimistic outlook on Matt Milano's status for Monday Night |
| 2021-10-16 | NFL analysts | Bills at Titans game predictions | Week 6 |
| 2021-10-17 | Josh Allen | At 50 games |
| 2021-10-18 | Continuity fuels the Bills secondary to become the NFL's best |
| 2021-10-18 | A.J. Epenesa, Boogie Basham inactive for Bills at Titans on Monday Night Football |
| 2021-10-18 | Bills at Titans | How to watch, stream, and listen | Week 6 |
| 2021-10-19 | Titans 34, Bills 31 | Game recap, highlights & photos |
| 2021-10-19 | Top 3 things we learned from Bills at Titans | Week 6 |
| 2021-10-19 | ‘Get through it and march on’ | Bills aim to use loss as motivation after the bye week |
| 2021-10-19 | Bills set points scored record for first six games + other numbers to know from Week 6 |
| 2021-10-19 | Bills peak at No. 2 in NFL power rankings | Week 7 |
| 2021-10-19 | Sean McDermott confirms Dawson Knox fractured his hand in Tennessee on Monday night |
| 2021-10-19 | 3 things we learned from Sean McDermott heading into the 2021 bye week |
| 2021-10-20 | Bills name Geno Allport 2021 Fan of the Year |
| 2021-10-21 | What they're saying | National experts express belief in the Bills at the bye week |
| 2021-10-22 | Meet Gary Powers | Bills Season Ticket Member of the Month |
| 2021-10-23 | What fans need to know about the Bills at the 2021 bye week |
| 2021-10-25 | Bills sign Buffalo native Evin Ksiezarczyk to the practice squad |
| 2021-10-26 | Bills remain among the top 5 teams in NFL power rankings | Week 8 |
| 2021-10-27 | Top 6 storylines for Bills vs. Dolphins | Week 8 |
| 2021-10-27 | Sean McDermott declares Dawson Knox out for Bills vs. Dolphins |
| 2021-10-27 | Bruce Smith is getting in the Halloween spirit with a quarterback graveyard |
| 2021-10-27 | Aiming for perfection | Bills understand there’s work to be done heading into the Miami game |
| 2021-10-28 | Brian Daboll remains focused despite enduring personal losses |
| 2021-10-28 | Ruben Brown set to return as the Bills Legend of the Game |
| 2021-10-29 | Why Tommy Sweeney is ready take advantage of his opportunity in the spotlight |
| 2021-10-29 | 6 things to watch for in Bills vs. Dolphins | Week 8 |
| 2021-10-29 | How Bills fans can support Zack Moss’s new clothing line |
| 2021-10-29 | Spencer Brown listed as doubtful for Bills vs. Dolphins |
| 2021-10-30 | NFL analysts | Bills vs. Dolphins game predictions | Week 8 |
| 2021-10-30 | Bills elevate Kahale Warring for Sunday’s game |
| 2021-10-30 | Bills vs. Dolphins | How to watch, stream, and listen | Week 8 |
| 2021-10-31 | Spencer Brown, Justin Zimmer inactive for Bills vs. Dolphins | Week 8 |
| 2021-10-31 | Phil Mickelson is a big fan of Josh Allen's Halloween costume |
| 2021-10-31 | Bills 26, Dolphins 11 | Game recap, highlights & photos |
