MDS's take: The Bills keep marching toward the playoffs thanks in large part to an easy schedule.
MDS's pick: Bills 38, Dolphins 14.
Florio's take: Even the Bills are 16.5-point favorites against the Gang That Couldn't Tank Straight. The Dolphins won't win in Ryan Fitzpatrick's return to Buffalo, but they'll keep it interesting.
Florio's pick: Bills 20, Dolphins 10.
What to watch for: The Bills have yet to employ an offense that includes both Devin Singletary and Duke Williams, each of whom offers a dynamic element. Look for offensive coordinator Brian Daboll to get creative with his new-look offense against the Dolphins' barely-there defense. -- Marcel Louis-Jacques
Bold prediction: To that point, the Bills rush for 250-plus yards. The Dolphins have the NFL's second-worst run defense, allowing 170 yards per game. The game plan should be easy for Buffalo: Attack Miami where it hurts. -- Cameron Wolfe
Wolfe's pick: Bills 27, Dolphins 10
Louis-Jacques' pick: Bills 35, Dolphins 7
The Bills are coming off their bye, so they will be rested. Their defense has been outstanding and Miami has offensive limitations. That's a bad combination. This will be a game for the Buffalo offense to come alive. Josh Allen has a good day.
Pick: Bills 31, Dolphins 13
The Dolphins (0-5) are either the worst team in the N.F.L. or tied for the worst with Cincinnati (0-6). The Bills (4-1) have one of the N.F.L.'s most dominant defenses, and with the rookie running back Devin Singletary expected to return and the ageless Frank Gore always ready to rumble, Buffalo can easily grind out games on the ground. Buffalo's offense is too conservative to justify a point spread of more than two touchdowns, but the thought of Buffalo losing this game at home is a bit preposterous.
Pick: Dolphins +17