When Kansas City's offense has the ball, this game will be a matchup of sides trying to live up to previous glory. The Chiefs are 12th in net yards per attempt after finishing first and second the previous two seasons. The Bills' defense went from mediocre to Lions status in Nashville, with Matt Milano and Tre'Davious White out of the lineup. K.C.'s offense seems like the far easier fix. Both Patrick Mahomes and Josh Allen are constantly trying to balance how much they should improvise versus how much they should stick to structure, and while Mahomes is a little out of whack currently, he's accustomed to being in shootouts. I'm curious if Bills coach Sean McDermott is ready to embrace playing every week in the 30-plus-point range, because that's the type of Bills team he's coaching.
Kansas City Chiefs 35, Buffalo Bills 30
The Bills looked bad against Tennessee, while the Chiefs didn't play well against the Raiders in their loss. So who re-groups here? I think if the Bills have Tre'Davious White back they will win it, and I think he will play. Josh Allen will beat Patrick Mahomes in a battle of gunslingers.
Pick: Bills 33, Chiefs 31
MDS's take: Both of these teams are coming off upset losses, but I trust the Chiefs more to bounce back quickly.
MDS's pick: Chiefs 21, Bills 17.
Florio's take: Desperation quickly sets in for a pair of previously 4-0 teams. The Chiefs tend to bring it when they think they must.
Florio's pick: Chiefs 31, Bills 24.
What to watch for: Bills wide receiver Stefon Diggs is averaging a career-high 101.8 yards per game in 2020, good for second in the NFL. The Chiefs, on the other hand, have allowed two 100-yard receivers through five games this season. Look for quarterback Josh Allen and Buffalo offensive coordinator Brian Daboll to push that number to three come Monday. -- Marcel Louis-Jacques
Stat to know: Kansas City quarterback Patrick Mahomes began his 2018 MVP season by completing 64% of his passes for 1,513 yards, 14 touchdowns, two interceptions and an 86.1 Total QBR through five games. That stat line isn't too far from what Allen has done through five games this season: 69% passing, 1,589 yards, 14 touchdowns, three interceptions and an 85.2 Total QBR.
Teicher's pick: Chiefs 31, Bills 27
Louis-Jacques' pick: Chiefs 38, Bills 34
This game got pushed back from its "Thursday Night Football" spotlight, and it's Buffalo's chance to shine on the national stage. The Chiefs were upset by the Raiders in Week 5, but they are more accustomed to this prime-time spot. Patrick Mahomes and Josh Allen put on a show, but the Chiefs come out on top.
Pick: Chiefs 33, Bills 24