Turron Davenport's pick: The Titans are in a groove offensively after Marcus Mariota exploded for almost 400 yards of total offense in Week 4. The wide receivers match up well against Buffalo's cornerbacks, and running back Dion Lewis should thrive catching passes out of the backfield. Defensive coordinator Dean Pees will dial up the interior gap blitzes and nickel blitzes to pressure Josh Allen into making careless throws. Titans 27, Bills 13
Mike Rodak's pick: The Bills' formula for fixing their 31st-ranked offense has been made clear all week: They want to run the ball more often on early downs and focus on quick, short throws when they decide to pass. The Titans have allowed the fourth-most yards per carry (5.04) on first and second downs this season, which might make Tennessee the perfect opponent to settle down a Josh Allen-led offense that turned the ball over three times and allowed seven sacks in a shutout loss last week. Bills 17, Titans 14
The Titans' offense is better than you think and the Bills’ defense is better than you think. They’ll meet somewhere in the middle here. This is a chance for Tennessee to play ball control with Marcus Mariota and the running game to stay away from Buffalo’s strengths in pass defense. Josh Allen can channel some of Carson Wentz’s success against the Titans' defense, but it won’t be enough.
PICK: Titans win 20-17