What to watch for: Josh Allen has yet to turn in four quarters of mistake-free football this season, but he'll need to against the Patriots. A large part of his game is his ability to improvise. Whether he'll be able to make smart improvisational decisions against an opportunistic New England defense will determine how successful the Bills' offense will be Sunday. -- Marcel Louis-Jacques
Bold prediction: Sony Michel will lead the way on offense for New England, as the Patriots' running game will find its groove after three outings in which the attack has trended more toward the pass. Michel, who has totaled only 108 rushing yards over three games, will top the 100-yard mark in a close contest that will be decided in the fourth quarter. -- Mike Reiss
Reiss' pick: Patriots 20, Bills 17
Louis-Jacques' pick: Patriots 21, Bills 13
Patriots (-7) at Bills — The Patriots are 3-0 against three winless teams. Fraud. The Bills are 3-0 against teams with a combined record of 1-8. Champion. In all seriousness, the Bills defense and Josh Allen's ability to make plays out of nothing make this a very attractive home dog. BILLS
This is a game with two 3-0 teams. Did I just write that? Yes, the Bills are undefeated as they ready to play the Patriots. They are good on defense, but face their biggest challenge here. I think they can handle it. Can Josh Allen handle the Patriots defense? I think he does just fine, but in the end the Patriots will win a close one.
Pick: Patriots 23, Bills 21
The Bills (3-0) have had a quietly excellent defense going back to last season, and thanks to some improvements in Buffalo's offensive efficiency, people seem to be catching on to how good this team really is. After rallying for a win against Cincinnati last week, Buffalo will get a chance to prove its hot start is not a fluke against the Patriots (3-0), who have been comically dominant on both sides of the ball.
No team can approach a game against New England with much confidence, but Buffalo has a lot going for it: Josh Allen has smoothed out some of the edges of his game, Frank Gore is inexplicably still out there running between the tackles in place of the injured Devin Singletary and Tre'Davious White and the team's defense make opposing teams pay for any mistakes. Asking for an upset may be too much, but the Bills have more of a shot than you might think, and they definitely have a chance to cover.
Pick: Bills +7