What to watch for: The Raiders' secondary is beat up, with rookie cornerback Damon Arnette reaggravating his broken right thumb and second-year safety Johnathan Abram dealing with shoulder and thumb injuries. And it faces Bills quarterback Josh Allen, the fourth player in NFL history with at least 1,000 passing yards (1,038), 10 passing TDs (10) and a passer rating of at least 120 (124.8) in his team's first three games of a season. With at least 300 passing yards and two touchdowns Sunday, Allen will join Steve Young and Peyton Manning as the only quarterbacks with at least those numbers in each of his first four games of a season. Yikes. -- Paul Gutierrez
Bold prediction: Buffalo running backs Devin Singletary and Zack Moss both score as the Bills rack up 150-plus rushing yards. While predicting big numbers for Allen is no longer bold, the same can't be said for the Bills' run game. The Raiders rank 28th in rushing yards allowed, paving the way for a monster day for Buffalo's runners. -- Marcel Louis-Jacques
Louis-Jacques' pick: Bills 31, Raiders 21
Gutierrez's pick: Bills 32, Raiders 23
MDS's take: Josh Allen is an MVP candidate, and he's going to keep it going against aRaiders Defensethat looked on Sunday like it has a lot of holes.
MDS's pick: Bills 28, Raiders 21
Florio's take: Josh Allen was pissed about the 25-point lead that got away. He'll be determined to build and hold a lead against a Vegas team that's surely feeling a little shell-shocked after losing in New England.
Florio's pick: Bills 30, Raiders 20
The Raiders could be without their rookie starters at wide receiver (Henry Ruggs III and Bryan Edwards) and will be without their rookie starter at cornerback (Damon Arnette). The cumulative impact of Vegas' injuries, especially on the offensive line, started to show up last week. The Bills may be without receiver John Brown this week, but with their own rookie speedster (Gabriel Davis) making plays, they might not even miss him.
If the Raiders are trying to play 1980s power football, the Bills' spread attack -- built around Josh Allen's mobility -- is a nod to the future. Never pick against progress, especially when it's matched up against this Raiders' defense. Devin Singletary is set up to have a day.
Buffalo Bills 30, Las Vegas Raiders 24
The Bills are riding high behind Josh Allen, but this is a long trip against a team coming off a loss. This is a be-careful game for the Bills. But I think Allen will win a shootout with Derek Carr as the Bills stay undefeated.
Pick: Bills 33, Raiders 31