Eric D. Williams' pick: The Chargers face the Bills for the second consecutive year, with Buffalo's quarterback -- rookie first-round pick Josh Allen -- making his first NFL start. The Bills hope Allen's debut does not go as badly as last season, when Nathan Peterman threw five interceptions in the first half of his debut. The Chargers are the better team and hungry for their first win after a humbling defeat to the Chiefs at home in their season opener last week. The Chargers have defeated the Bills in their past three meetings. Chargers 27, Bills 20
Mike Rodak's pick: Joey Bosa, who pressured or hit Peterman on all five of his interceptions last season, will not play Sunday. Neither will Eric Wood and Richie Incognito, the Bills' two best offensive linemen from last season's game, who both retired. With Allen making his first career start, the Chargers still have the advantage. Chargers 27, Bills 17
It would be just like the NFL for the Bills to win here after everyone has laughed at them for a week. I don't know exactly how they can keep it close in Josh Allen's first start, but I do know the Chargers didn't look good last week either and now they're in the tough "West Coast team in a 10 a.m. Pacific time start" situation. Bills over Chargers.
The Chargers (0-1) played fairly well offensively in Week 1, but their defense was no match for the Chiefs. The Bills (0-1), even with Josh Allen at quarterback, are not the Chiefs. Pick: Chargers
Whether or not the Bills made the right choice by starting Josh Allen is up for debate, but I don't seeing it making much of an impact against a Chargers team that racked up 540-plus yards in last week's loss to the Chiefs. Pick: Chargers