Michael Rothstein's pick: Somehow, the Lions are still in contention for a playoff berth, and winning in Buffalo would keep the franchise's postseason hopes alive for at least one more week. Yes, the offense is incredibly beat up, but the defense has improved over the past month, holding three of their past four opponents under 25 points. It will help that Buffalo has the second-worst offense in the league in yards and points scored. That should be enough for the Lions to win their second straight yawnfest. Lions 20, Bills 10
Mike Rodak's pick: The Bills are 4-0 this season when they have a positive turnover margin and 0-9 with an even or negative turnover margin, so it's no secret the Bills must protect the ball to beat the Lions. That is an attainable goal for Josh Allen, who will face a Detroit defense that is tied for second-fewest interceptions this season. Buffalo is 2-7 against defenses in the top half of the NFL in interceptions and 2-2 against teams, such as the Lions, in the bottom half. Bills 21, Lions 17
Throwback Thursday: Bills vs. Lions Through the Years
The Bills are hosting the Detroit Lions at New Era Field for a Week 15 matchup. To get ready for the game, take a look back at the opponents through the years.