| 2022-09-01 | Bills sign punter Sam Martin |
| 2022-09-01 | Bills for The Six |
| 2022-09-01 | Bills sign 3 more players to complete practice squad |
| 2022-09-01 | Stefon Diggs’ Back to School Bash impacts East Buffalo neighborhood |
| 2022-09-01 | Bills GM Brandon Beane on Tre White's timetable, more roster decisions |
| 2022-09-02 | Bills Block Party on Chippewa returns for third season |
| 2022-09-02 | Why Bills CB Christian Benford isn't taking his rookie season for granted |
| 2022-09-03 | Top 5 storylines to follow for Bills at Rams | 2022 NFL Kickoff |
| 2022-09-03 | In focus: The stories behind our favorite Bills preseason photos |
| 2022-09-04 | Aggressive and ultra-competitive, Ken Dorsey poised to lift Buffalo’s offense higher |
| 2022-09-04 | Bills name nine captains for the 2022 season |
| 2022-09-04 | From the Locker Room | What to expect from the Rams — NFL Kickoff Game excitement |
| 2022-09-05 | "They’ve built the right team" | How Bills GM Brandon Beane, HC Sean McDermott have turned Buffalo into a Super Bowl contender |
| 2022-09-05 | Bills Today | Rookie CBs Kaiir Elam and Christian Benford expected to split snaps on Thursday night at Rams |
| 2022-09-05 | Buffalo a "second home" to Bills TE Dawson Knox |
| 2022-09-06 | Fisher-Price® releases Little People® Go Bills! figure set for 2022 |
| 2022-09-06 | Joe Suhr & Tim Rose earn Bills-ADPRO Sports high school coach of the week honors | Week 1 2022 |
| 2022-09-06 | 6 things to watch for in Bills vs. Rams | Thursday Night Football |
| 2022-09-07 | Renowned artist and activist Ruben Rojas’ sculptures encourage fans to 'Choose Love' |
| 2022-09-07 | Bills list TE Quintin Morris, OT Tommy Doyle as questionable vs. Rams |
| 2022-09-07 | Bills sign TE Dawson Knox to four-year contract extension |
| 2022-09-07 | Bills Today | Season predictions for the 2022 Buffalo Bills |
| 2022-09-07 | "The perfect Hollywood story" | Josh Allen's rise to stardom a tailor-made pairing with NFL Kickoff game in Los Angeles |
| 2022-09-08 | Loving life with the Buffalo Bills, Von Miller hopes more "big moments" are on the horizon in latest football chapter |
| 2022-09-08 | Game predictions | Bills vs. Rams | Thursday Night Football |
| 2022-09-08 | Bills list five players inactive vs. Rams | Thursday Night Football Week 1 |
| 2022-09-09 | Bills vs. Rams | How to watch, stream, and listen | Thursday Night Football 2022 Week 1 |
| 2022-09-09 | Josh Allen's heroic second half leads Bills over Rams 31-10 | Recap of highlights, top things to know |
| 2022-09-09 | Bills draw rave reviews with statement victory over Rams | Social Media recap |
| 2022-09-09 | Top 3 things we learned from Bills vs. Rams | Week 1 2022 |
| 2022-09-09 | "Everybody wanted this game" | Bills superstars shine on the big stage in LA |
| 2022-09-09 | Bills put up historic stats in 31-10 win over the Rams |
| 2022-09-10 | Bills Today | QB Josh Allen leads NFL jersey sales at start of the season |
| 2022-09-12 | Bills 50/50 raffle is going digital |
| 2022-09-12 | Bills Today | TODAY Show highlights Bills equipment staff + Von Miller earns praise from Peter King |
| 2022-09-12 | Consulting with the coaches: On Von Miller's usage, offense's third down success rate |
| 2022-09-13 | Bills Foundation 2022 Garage Sale |
| 2022-09-13 | Jeremy Zimmer & Steve Smith earn Bills-ADPRO Sports high school coach of the week honors | Week 2 2022 |
| 2022-09-13 | Bills Today | A look at the past five Bills home openers |
| 2022-09-13 | New series “The Roadmap” presented by Northtown to highlight leadership of Sean McDermott, Brandon Beane |
| 2022-09-14 | Top 5 storylines for Bills vs. Titans | Monday Night Football 2022 Week 2 |
| 2022-09-14 | Bills DT Ed Oliver (ankle) won't practice Wednesday |
| 2022-09-14 | Bills players prep for "very, very tough" MNF game vs. Titans |
| 2022-09-15 | Jim Kelly to serve as Bills Legend of the Game | Monday Night Football | Week 2 |
| 2022-09-15 | Caesars Sportsbook to kick off its truck tour at Highmark Stadium for Bills home opener |
| 2022-09-15 | Bills Today | DaQuan Jones and Dawson Knox have different reasons to be excited to face Tennessee |
| 2022-09-16 | 6 things to watch for in Bills vs. Titans | Monday Night Football Week 2 2022 |
| 2022-09-17 | Bills Today | Josh Allen's father, Joel Allen, sings National Anthem before Wyoming football game |
| 2022-09-17 | Bills rule out DT Ed Oliver; three other players carry injury tags for home opener vs. Titans |
| 2022-09-18 | Game predictions | Bills vs. Titans | Monday Night Football |
| 2022-09-18 | What Bills fans need to know about the Monday Night Football pregame ceremony |
| 2022-09-19 | Buffalo is ready for Monday Night Football and an "absolutely bananas" environment |
| 2022-09-19 | Bills rule out 7 players vs. Titans | Monday Night Football Week 2 |
| 2022-09-19 | Bills vs. Titans | How to watch, stream and listen | Monday Night Football Week 2 2022 |
| 2022-09-20 | Bills provide an update on Dane Jackson |
| 2022-09-20 | Bills blowout Titans 41-7 on MNF behind career nights from Josh Allen and Stefon Diggs |
| 2022-09-20 | Social media reacts to Bills' thumping of Titans | MNF Week 2 |
| 2022-09-20 | Top 3 things we learned from Bills vs. Titans | Week 2 |
| 2022-09-20 | “We’re very grateful to be able to do this” | Bills rally together as a team in light of injuries |
| 2022-09-20 | Bills issue an update on cornerback Dane Jackson |
| 2022-09-20 | Rich Gray & Mike Stumpf earn Bills-ADPRO Sports high school coach of the week honors | Week 3 2022 |
| 2022-09-20 | Josh Allen, Stefon Diggs have record-setting night | Best stats to know from Bills' win over Titans |
| 2022-09-20 | Bills Today | 6 former Bills make the list of Modern-Era Nominees for the Pro Football Hall of Fame’s Class of 2023 |
| 2022-09-21 | Bills Backers Miami ready to bring the heat this weekend in South Florida |
| 2022-09-21 | Top 6 storylines to follow for Bills at Dolphins | Week 3 |
| 2022-09-21 | Dion Dawkins' teacher appreciation dinner supports Buffalo's East Side |
| 2022-09-21 | Bills to use "a collective effort" to slow down Dolphins WRs |
| 2022-09-22 | Bills introduce Mini Mafia Kids Club |
| 2022-09-22 | Bills Today | Sean McDermott shares Bills injury updates ahead of Thursday's practice |
| 2022-09-22 | "He's done a good job" | QB Josh Allen praises Tua, Bills stay ready for AFC East showdown |
| 2022-09-23 | 6 things to watch for in Bills vs. Dolphins | Week 3 |
| 2022-09-23 | Injury update: Bills to be without S Micah Hyde (neck), DT Jordan Phillips (hamstring) and CB Dane Jackson (neck) vs. Dolphins |
| 2022-09-23 | Bills Today | "I'm in the position I always wanted to be in" — Bills rookie cornerbacks ready to step up |
| 2022-09-24 | Game predictions | Bills vs. Dolphins | Week 3 |
| 2022-09-24 | Bills place Micah Hyde on injured reserve; Bryant & Emili signed to 53-man roster |
| 2022-09-25 | Trends and milestones to watch for in Bills vs. Dolphins | Week 3 |
| 2022-09-25 | Bills list inactives vs. Miami | Week 3 |
| 2022-09-25 | Bills vs. Dolphins | How to watch, stream and listen | Week 3 2022 |
| 2022-09-25 | Bills fall just short of fourth quarter comeback, lose 21-19 to Dolphins |
| 2022-09-25 | Top 3 things we learned from Bills vs. Dolphins | Week 3 |
| 2022-09-26 | “This team's got no quit in us” | Bills players and coaches stay confident following loss |
| 2022-09-26 | Bills Today | Josh Allen nominated for this week’s FedEx Air NFL Player of the Week Award |
| 2022-09-26 | Sean McDermott updates Bills injuries going into Week 4 |
| 2022-09-27 | Mike Torrillo & Tim Sawyer earn Bills-ADPRO Sports high school coach of the week honors | Week 4 2022 |
| 2022-09-27 | Gary Schmidt named Bills Season Ticket Member of the Month for September |
| 2022-09-27 | Bills OC Ken Dorsey on late-game situations and "missed opportunities" to win in Miami |
| 2022-09-27 | Bills sign former Cardinals OL Justin Murray, place OT Tommy Doyle on IR |
| 2022-09-28 | Bills add veteran cornerback Xavier Rhodes to the practice squad |
| 2022-09-28 | Bills fans are ready to charm the city of Baltimore |
| 2022-09-28 | Top 6 storylines to follow for Bills vs. Ravens | Week 4 |
| 2022-09-28 | Bills players help kick off the Play 60 Challenge |
| 2022-09-28 | "I can't do anything else but smile" | Dane Jackson 'feels good' after first practice back with the team |
| 2022-09-29 | "Crazy to think about" | Josh Allen & Lamar Jackson intertwined by 2018 Draft, dual-threat prowess |
| 2022-09-29 | Bills Today | "Stay ready" mentality from CB Xavier Rhodes helps him fit right into Bills' locker room |
| 2022-09-30 | 6 things to watch for in Bills vs. Ravens | Week 4 |
| 2022-09-30 | Bills rule 3 players out, list 7 others as questionable vs. Ravens | Week 4 |
